Antitarget, anti-SARS-CoV-2 leads, drugs, and the drug discovery–genetics alliance perspective
The most advanced antiviral molecules addressing major SARS-CoV-2 targets (Main
protease, Spike protein, and RNA polymerase), compared with proteins of other human …
protease, Spike protein, and RNA polymerase), compared with proteins of other human …
The discovery and development of transmembrane serine protease 2 (TMPRSS2) inhibitors as candidate drugs for the treatment of COVID-19
C Mantzourani, S Vasilakaki… - Expert Opinion on …, 2022 - Taylor & Francis
ABSTRACT Introduction Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
has caused the devastating pandemic named coronavirus disease 2019 (COVID-19) …
has caused the devastating pandemic named coronavirus disease 2019 (COVID-19) …
Molecular basis of TMPRSS2 recognition by Paeniclostridium sordellii hemorrhagic toxin
Hemorrhagic toxin (TcsH) is a major virulence factor produced by Paeniclostridium sordellii,
which is a non-negligible threat to women undergoing childbirth or abortions. Recently …
which is a non-negligible threat to women undergoing childbirth or abortions. Recently …
Medications modulating the acid sphingomyelinase/ceramide system and 28-day mortality among patients with SARS-CoV-2: an observational study
Prior evidence indicates the potential central role of the acid sphingomyelinase
(ASM)/ceramide system in the infection of cells with SARS-CoV-2. We conducted a …
(ASM)/ceramide system in the infection of cells with SARS-CoV-2. We conducted a …
Challenges and toxicity assessment of inorganic nanomaterials in biomedical applications: Current status and future roadmaps
P Mahamuni-Badiger, MJ Dhanavade - Journal of Drug Delivery Science …, 2023 - Elsevier
Nano-world is expanding rapidly due to the amalgamation of different science disciplines.
Nanomaterials (NMs) have wide applications in the biomedical field due to their unique …
Nanomaterials (NMs) have wide applications in the biomedical field due to their unique …
Transmembrane protease serine 2 proteolytic cleavage of the SARS-CoV-2 spike protein: a mechanistic quantum mechanics/molecular mechanics study to inspire the …
LMC Teixeira, JTS Coimbra, MJ Ramos… - Journal of Chemical …, 2022 - ACS Publications
Despite the development of vaccines against the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) virus, there is an urgent need for efficient drugs to treat infected …
coronavirus 2 (SARS-CoV-2) virus, there is an urgent need for efficient drugs to treat infected …
Beyond the lungs: exploring diverse applications of bromhexine and ambroxol
The respiratory tract is commonly affected in multisystem disorders. Although many drugs
have been developed to target various components of these diseases, there is still a need …
have been developed to target various components of these diseases, there is still a need …
Host cell proteases mediating SARS-CoV-2 entry: An overview
M Oubahmane, I Hdoufane, I Bjij… - Current Topics in …, 2022 - ingentaconnect.com
The outbreak of the SARS-CoV-2 virus in late 2019 and the spread of the COVID-19
pandemic have caused severe health and socioeconomic damage worldwide. Despite the …
pandemic have caused severe health and socioeconomic damage worldwide. Despite the …
DON/DRP‐104 as potent serine protease inhibitors implicated in SARS‐CoV‐2 infection: Comparative binding modes with human TMPRSS2 and novel therapeutic …
E Oduro‐Kwateng, ME Soliman - Journal of Cellular …, 2024 - Wiley Online Library
Human transmembrane serine protease 2 (TMPRSS2) is an important member of the type 2
transmembrane serine protease (TTSP) family with significant therapeutic markings. The …
transmembrane serine protease (TTSP) family with significant therapeutic markings. The …
In Silico Molecular Characterization of Human TMPRSS2 Protease Polymorphic Variants and Associated SARS-CoV-2 Susceptibility
The 2019 coronavirus disease (COVID-19) pandemic continues to challenge health care
systems worldwide. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has …
systems worldwide. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has …