TCR recognition of peptide–MHC-I: Rule makers and breakers
T cells are a critical part of the adaptive immune system that are able to distinguish between
healthy and unhealthy cells. Upon recognition of protein fragments (peptides), activated T …
healthy and unhealthy cells. Upon recognition of protein fragments (peptides), activated T …
Predicting cross-reactivity and antigen specificity of T cell receptors
Adaptive immune recognition is mediated by specific interactions between heterodimeric T
cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to …
cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to …
Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy
The T cells of the immune system can target tumors and clear solid cancers following tumor-
infiltrating lymphocyte (TIL) therapy. We used combinatorial peptide libraries and a …
infiltrating lymphocyte (TIL) therapy. We used combinatorial peptide libraries and a …
VDJdb: a curated database of T-cell receptor sequences with known antigen specificity
The ability to decode antigen specificities encapsulated in the sequences of rearranged T-
cell receptor (TCR) genes is critical for our understanding of the adaptive immune system …
cell receptor (TCR) genes is critical for our understanding of the adaptive immune system …
CRISPR-mediated TCR replacement generates superior anticancer transgenic T cells
Adoptive transfer of T cells genetically modified to express a cancer-specific T-cell receptor
(TCR) has shown significant therapeutic potential for both hematological and solid tumors …
(TCR) has shown significant therapeutic potential for both hematological and solid tumors …
Thioamide Analogues of MHC I Antigen Peptides
R Gibadullin, RK Morris, J Niu, J Sidney… - Journal of the …, 2023 - ACS Publications
Short, synthetic peptides that are displayed by major histocompatibility complex I (MHC I)
can stimulate CD8 T cells in vivo to destroy virus-infected or cancer cells. The development …
can stimulate CD8 T cells in vivo to destroy virus-infected or cancer cells. The development …
Multi-tiered approach to detect autoimmune cross-reactivity of therapeutic T cell receptors
K Ishii, JS Davies, AL Sinkoe, KA Nguyen… - Science …, 2023 - science.org
T cell receptor (TCR)–engineered T cell therapy using high-affinity TCRs is a promising
treatment modality for cancer. Discovery of high-affinity TCRs especially against self …
treatment modality for cancer. Discovery of high-affinity TCRs especially against self …
[HTML][HTML] Innate and adaptive immune responses toward nanomedicines
IM de Oliveira Viana, S Roussel, J Defrêne… - … Pharmaceutica Sinica B, 2021 - Elsevier
Since the commercialization of the first liposomes used for drug delivery, Doxil/Caelyx® and
Myocet®, tremendous progress has been made in understanding interactions between …
Myocet®, tremendous progress has been made in understanding interactions between …
Role of T cell receptor affinity in the efficacy and specificity of adoptive T cell therapies
Over the last several years, there has been considerable progress in the treatment of cancer
using gene modified adoptive T cell therapies. Two approaches have been used, one …
using gene modified adoptive T cell therapies. Two approaches have been used, one …
T cell immunity following COVID-19 vaccination in adult patients with primary antibody deficiency–a 22-month follow-up
A Hurme, P Jalkanen, M Marttila-Vaara… - Frontiers in …, 2023 - frontiersin.org
Primary antibody deficiencies, such as common variable immunodeficiency (CVID), are
heterogenous disease entities consisting of primary hypogammaglobulinemia and impaired …
heterogenous disease entities consisting of primary hypogammaglobulinemia and impaired …