Hijacking of the AP-1 signaling pathway during development of ATL

H Gazon, B Barbeau, JM Mesnard… - Frontiers in …, 2018 - frontiersin.org
Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of a fatal malignancy
known as adult T-cell leukemia (ATL). One way to address the pathology of the disease lies …

Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation

M Matsuoka, KT Jeang - Nature Reviews Cancer, 2007 - nature.com
It has been 30 years since a'new'leukaemia termed adult T-cell leukaemia (ATL) was
described in Japan, and more than 25 years since the isolation of the retrovirus, human T …

Adult T-cell leukemia: molecular basis for clonal expansion and transformation of HTLV-1–infected T cells

T Watanabe - Blood, The Journal of the American Society of …, 2017 - ashpublications.org
Adult T-cell leukemia (ATL) is an aggressive T-cell malignancy caused by human T-cell
leukemia virus type 1 (HTLV-1) that develops through a multistep carcinogenesis process …

Human T-cell leukemia virus type 1 (HTLV-1) and leukemic transformation: viral infectivity, Tax, HBZ and therapy

M Matsuoka, KT Jeang - Oncogene, 2011 - nature.com
The human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus discovered to be
causative of a human cancer, adult T-cell leukemia. The transforming entity of HTLV-1 has …

The HTLV-1 tax interactome

M Boxus, JC Twizere, S Legros, JF Dewulf, R Kettmann… - Retrovirology, 2008 - Springer
The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant
of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling …

How I treat adult T-cell leukemia/lymphoma

A Bazarbachi, F Suarez, P Fields… - Blood, The Journal of …, 2011 - ashpublications.org
Adult T-cell leukemia/lymphoma (ATL) is an aggressive malignancy of mature activated T
cells caused by human T-cell lymphotropic virus type I. ATL carries a bad prognosis …

Mechanisms of HTLV-1 persistence and transformation

M Boxus, L Willems - British journal of cancer, 2009 - nature.com
Adult T-cell leukaemia (ATL) is caused by the human T-cell lymphotropic virus type 1 (HTLV-
1). HTLV-1 has elaborated strategies to persist and replicate in the presence of a strong …

Oncogenic mutations in the FBXW7 gene of adult T-cell leukemia patients

CH Yeh, M Bellon… - Proceedings of the …, 2016 - National Acad Sciences
Human T-cell leukemia virus type 1 (HTLV-I) is associated with adult T-cell leukemia (ATL),
an aggressive lymphoproliferative disease with a dismal prognosis. We have previously …

Hypericin-photodynamic therapy inhibits the growth of adult T-cell leukemia cells through induction of apoptosis and suppression of viral transcription

L Xu, X Zhang, W Cheng, Y Wang, K Yi, Z Wang… - Retrovirology, 2019 - Springer
Background Adult T-cell leukemia (ATL) is an aggressive neoplasm caused by human T-cell
leukemia virus type 1 (HTLV-1). ATL carries a poor prognosis due to chemotherapy …

ATF3, an HTLV-1 bZip factor binding protein, promotes proliferation of adult T-cell leukemia cells

K Hagiya, J Yasunaga, Y Satou, K Ohshima… - Retrovirology, 2011 - Springer
Background Adult T-cell leukemia (ATL) is an aggressive malignancy of CD4+ T-cells
caused by human T-cell leukemia virus type 1 (HTLV-1). The HTLV-1 bZIP factor (HBZ) …