Protein–protein interactions within protein networks shape the human interactome, which
often is promoted by specialized protein interaction modules, such as the postsynaptic …

There are promising new therapeutic agents for CRC patients, including novel small-
molecule inhibitors and immune checkpoint blockers. We focused on emerging CRC's …

Mytilus is an economically important bivalve and its shell is a biomineralized tissue with
various microstructures/layers. In the present study, the shell of marine mussel, Mytilus …

While allostery is of paramount importance for protein regulation, the underlying dynamical
process of ligand (un) binding at one site, resulting time evolution of the protein structure …

Multi-enzyme complexes designed based on scaffold proteins are a current topic in
molecular enzyme engineering. They have been gradually applied to increase the …

Abstract γ-Aminobutyric acid type A and glycine receptors (GABAARs, GlyRs) are the major
inhibitory neurotransmitter receptors and contribute to many synaptic functions, dysfunctions …

Several molecules have been identified as receptors or coreceptors for rotavirus infection,
including glycans, integrins, and hsc70. In this work we report that the tight junction proteins …

LIM domain kinases (LIMK) are important regulators of actin cytoskeletal remodeling. These
protein kinases phosphorylate the actin depolymerizing factor cofilin to suppress filament …

While allostery is of paramount importance for protein signaling and regulation, the
underlying dynamical process of allosteric communication is not well understood. The PDZ3 …

Synaptic plasticity enhances or reduces connections between neurons, affecting learning
and memory. Postsynaptic AMPARs mediate greater than 90% of the rapid excitatory …