Pyroptosis is a novel inflammatory form of regulated cell death (RCD), characterized by cell
swelling, membrane rupture, and pro-inflammatory effects. It is recognized as a potent …

More than 800 million people suffer from kidney disease. Genetic studies and follow-up
animal models and cell biological experiments indicate the key role of proximal tubule …

Rhabdomyolysis is a severe condition that commonly leads to acute kidney injury (AKI).
While double-stranded DNA (dsDNA) released from injured muscle can be involved in its …

Background Two variants in the gene encoding apolipoprotein L1 (APOL1) that are highly
associated with African ancestry are major contributors to the large racial disparity in rates of …

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by aberrant
development of B cells and excess production of autoantibodies. Our team previously …

Psoriasis is a chronic inflammatory skin disease occurring worldwide, with multiple systemic
complications, which seriously affect the quality of life and physical and mental health of …

Mitophagy is an important mechanism for mitochondrial quality control by regulating
autophagosome-specific phagocytosis, degradation and clearance of damaged …

The NLRP3 receptor can assemble inflammasome platforms to trigger inflammatory
responses; however, accumulating evidence suggests that it can also display anti …

Inflammasomes are multiprotein complexes assembled in response to pathogen-and
damage-associated molecular patterns (PAMPs and DAMPs) and cellular stress …

Long non‑coding RNAs (lncRNAs) are ncRNA transcripts> 200 nucleotides that are
important genetic regulators. LncRNAs can directly regulate mRNA through a lncRNA …