This is the third in a series of Perspectives on intracellular signaling pathways coupled to
proliferation in pancreatic β-cells. We contrast the large knowledge base in rodent β-cells …

Diabetes is a major health issue of increasing prevalence. ß‐cell replacement, by pancreas
or islet transplantation, is the only long‐term curative option for patients with insulin …

Islet transplantation has poor long-term efficacy because of the lack of extracellular matrix
support and neovascularization; this limits its wide application in diabetes research. In this …

Maintaining long-term euglycemia after intraportal islet transplantation is hampered by the
considerable islet loss in the peri-transplant period attributed to inflammation, ischemia and …

Diabetes mellitus, a disease that affects nearly 536.6 million people worldwide, is
characterized by the death or dysfunction of insulin-producing beta cells of the pancreas …

Harnessing the translational potential of the GLP-1/GLP-1R system in pancreatic beta cells
has led to the development of established GLP-1R-based therapies for the long-term …

Pancreatic β-cells have been reported to be mechanosensitive to cellular
microenvironments, and subjecting the cells to more physiologically relevant …

Blood vessels course through organs, providing them with essential nutrient and gaseous
exchange. However, the vasculature has also been shown to provide non-nutritional signals …

The aim of this study was to assess whether cadherin-mediated adhesion of human islet
cells was affected by insulin secretagogues and explore the role of cadherins in the …

Background Multipotent mesenchymal stromal cells (MSC) enhance viability and function of
islets of Langerhans. We aimed to examine the interactions between human MSC and …