A multi-tissue atlas of regulatory variants in cattle
Abstract Characterization of genetic regulatory variants acting on livestock gene expression
is essential for interpreting the molecular mechanisms underlying traits of economic value …
is essential for interpreting the molecular mechanisms underlying traits of economic value …
Advancing fish breeding in aquaculture through genome functional annotation
Genomics is increasingly applied in breeding programmes for farmed fish and shellfish
species around the world. However, current applications do not include information on …
species around the world. However, current applications do not include information on …
Identification of genomic variants causing variation in quantitative traits: a review
Many of the important traits of livestock are complex or quantitative traits controlled by
thousands of variants in the DNA sequence of individual animals and environmental factors …
thousands of variants in the DNA sequence of individual animals and environmental factors …
Genetic variation in histone modifications and gene expression identifies regulatory variants in the mammary gland of cattle
Background Causal variants for complex traits, such as eQTL are often found in non-coding
regions of the genome, where they are hypothesised to influence phenotypes by regulating …
regions of the genome, where they are hypothesised to influence phenotypes by regulating …
Gene expression and RNA splicing explain large proportions of the heritability for complex traits in cattle
Many quantitative trait loci (QTLs) are in non-coding regions. Therefore, QTLs are assumed
to affect gene regulation. Gene expression and RNA splicing are primary steps of …
to affect gene regulation. Gene expression and RNA splicing are primary steps of …
Comparative epigenomics reveals the impact of ruminant-specific regulatory elements on complex traits
S Chen, S Liu, S Shi, Y Jiang, M Cao, Y Tang, W Li… - BMC biology, 2022 - Springer
Background Insights into the genetic basis of complex traits and disease in both human and
livestock species have been achieved over the past decade through detection of genetic …
livestock species have been achieved over the past decade through detection of genetic …
A comprehensive catalogue of regulatory variants in the cattle transcriptome
Abstract Characterization of genetic regulatory variants acting on the transcriptome of
livestock is essential for interpreting the molecular mechanisms underlying traits of …
livestock is essential for interpreting the molecular mechanisms underlying traits of …
[HTML][HTML] Cross-species enhancer prediction using machine learning
Cis-regulatory elements (CREs) are non-coding parts of the genome that play a critical role
in gene expression regulation. Enhancers, as an important example of CREs, interact with …
in gene expression regulation. Enhancers, as an important example of CREs, interact with …
Allele specific binding of histone modifications and a transcription factor does not predict allele specific expression in correlated ChIP-seq peak-exon pairs
CP Prowse-Wilkins, J Wang, JB Garner… - Scientific Reports, 2023 - nature.com
Allele specific expression (ASE) is widespread in many species including cows. Therefore,
regulatory regions which control gene expression should show cis-regulatory variation …
regulatory regions which control gene expression should show cis-regulatory variation …
Butyrate induces modifications of the CTCF-binding landscape in cattle cells
Butyrate is produced in the rumen from microbial fermentation and is related to several
functions, including cell differentiation and proliferation. Butyrate supplementation in calves …
functions, including cell differentiation and proliferation. Butyrate supplementation in calves …