[HTML][HTML] Interactions Involving Glycine and Other Amino Acid Neurotransmitters: Focus on Transporter-Mediated Regulation of Release and Glycine–Glutamate …

L Raiteri - Biomedicines, 2024 - mdpi.com
Glycine plays a pivotal role in the Central Nervous System (CNS), being a major inhibitory
neurotransmitter as well as a co-agonist of Glutamate at excitatory NMDA receptors …

PROcedure-SPECific postoperative pain management guideline for laparoscopic colorectal surgery: A systematic review with recommendations for postoperative pain …

P Lirk, J Badaoui, M Stuempflen… - European Journal of …, 2024 - journals.lww.com
Colorectal cancer is the second most common cancer diagnosed in women and third most
common in men. Laparoscopic resection has become the standard surgical technique …

Novel Phenylene Lipids That Are Positive Allosteric Modulators of Glycine Receptors and Inhibitors of Glycine Transporter 2

CI Gallagher, ZJ Frangos, D Sheipouri… - ACS Chemical …, 2023 - ACS Publications
Chronic pain is a complex condition that remains resistant to current therapeutics. We
previously synthesized a series of N-acyl amino acids (NAAAs) that inhibit the glycine …

Reduction of postoperative pain and opioid consumption by VVZ-149, first-in-class analgesic molecule: A confirmatory phase 3 trial of laparoscopic colectomy

HJ Lee, JY Sim, I Song, SS Nedeljkovic, DK Kim… - Journal of Clinical …, 2025 - Elsevier
Study objective VVZ-149 is a small molecule that inhibits the glycine transporter type 2 and
the serotonin receptor 5-hydroxytryptamine 2 A. In this Phase 3 study, we investigated the …

Actualización en el manejo del dolor agudo postquirúrgico en pacientes jóvenes sometidos a cirugía laparoscópica abdominal.

CF Rosero Guerrero, KM Guamani Carrillo - 2024 - dspace.unach.edu.ec
La gestión del dolor agudo postquirúrgico en pacientes jóvenes es un aspecto crucial en la
recuperación tras una cirugía laparoscópica abdominal. Este texto tiene como objetivo …

[PDF][PDF] Discovery of a Novel Multitarget Analgesic Through an In Vivo-guided Approach

G Zhen, N Do, N Van Manh, HJ Ha, H Kim, H Kim… - 2024 - preprints.org
Pain is a multifaceted condition influenced by peripheral, central, immune, and
psychological factors. Targeting multiple pathways provides a holistic approach, enhancing …

[PDF][PDF] Opioidien tarvetta vähentävät kivunhoitomenetelmät paksu-ja peräsuolen syövän leikkauksen jälkeen-kirjallisuuskatsaus

I Pajala - utupub.fi
Leikkausmenetelmä: paksu-ja peräsuolen syöpä, laparoskooppinen (26), avoin (32)
Potilasmäärä: 58 potilasta, 28 tutkimusryhmässä, 30 kontrolliryhmässä Tutkimusasetelma …