Ovarian cancer is the most lethal gynecological malignancy. It is usually diagnosed at a late
stage, with a 5-yr survival rate of< 30%. The majority of ovarian cancer cases are diagnosed …

Yin Yang‐1 (YY1) is a zinc finger protein and member of the GLI‐Kruppel family that can
activate or inactivate gene expression depending on interacting partners, promoter context …

Purpose AZD1775 is a first-in-class, potent, and selective inhibitor of WEE1 with proof of
chemopotentiation in p53-deficient tumors in preclinical models. In a phase I study, the …

Purpose: The study aim to identify novel molecular subtypes of ovarian cancer by gene
expression profiling with linkage to clinical and pathologic features. Experimental Design …

Molecular profiling of tumors promises to advance the clinical management of cancer, but
the benefits of integrating molecular data with traditional clinical variables have not been …

We introduce a framework for feature selection based on dependence maximization
between the selected features and the labels of an estimation problem, using the Hilbert …

Background Whether tumor mutation burden (TMB) correlated with improved survival
outcomes or promotion of immunotherapies remained controversy in various malignancies …

The cancer stem cell hypothesis posits that malignant growth arises from a rare population
of progenitor cells within a tumor that provide it with unlimited regenerative capacity. Such …

Despite the existence of morphologically indistinguishable disease, patients with advanced
ovarian tumors display a broad range of survival end points. We hypothesize that gene …

Biomarkers that predict disease progression might assist the development of better
therapeutic strategies for aggressive cancers, such as ovarian cancer. Here, we investigated …