Severe malaria is a medical emergency. It is a major cause of preventable childhood death
in tropical countries. Severe malaria justifies considerable global investment in malaria …

Malaria is a highly inflammatory and oxidative disease. The production of reactive oxygen
species by host phagocytes is an essential component of the host response to Plasmodium …

Intravascular haemolysis is a fundamental feature of chronic hereditary and acquired
haemolytic anaemias, including those associated with haemoglobinopathies, complement …

Malaria affected an estimated 216 million people causing 445,000 deaths in 2016. 1 This
reduced burden of disease and death is a result of more than a century of worldwide effort …

Purpose Acute kidney injury (AKI) frequently occurs in critically ill patients and often
precipitates use of renal replacement therapy (RRT). However, the ideal circumstances for …

Reactive oxygen species (ROS) released in cells are signaling molecules but can also
modify signaling proteins. Red blood cells perform a major role in maintaining the balance of …

Hemolysis is a pathological feature of several diseases of diverse etiology such as
hereditary anemias, malaria, and sepsis. A major complication of hemolysis involves the …

Malaria remains a major public health threat in tropical and subtropical regions across the
world. Even though less than 1% of malaria infections are fatal, this leads to about 430,000 …

Acute kidney injury (AKI) is emerging as a complication of increasing clinical importance
associated with substantial morbidity and mortality in African children with severe malaria …

Infections with Plasmodium falciparum and Plasmodium vivax cause over 600,000 deaths
each year, concentrated in Africa and in young children, but much of the world's population …