[HTML][HTML] Bioengineering the vascularized endocrine pancreas: a fine-tuned interplay between vascularization, extracellular-matrix-based scaffold architecture, and …

C Pignatelli, F Campo, A Neroni… - Transplant …, 2022 - frontierspartnerships.org
Intrahepatic islet transplantation is a promising β-cell replacement strategy for the treatment
of type 1 diabetes. Instant blood-mediated inflammatory reactions, acute inflammatory storm …

Immune-protective formulations and process strategies for improved survival and function of transplanted islets

Y Shi, YZ Zhao, Z Jiang, Z Wang, Q Wang… - Frontiers in …, 2022 - frontiersin.org
Type 1 diabetes (T1D) is an autoimmune disease caused by the immune system attacking
and destroying insulin-producing β cells in the pancreas. Islet transplantation is becoming …

ECM-based bioactive microencapsulation significantly improves islet function and graft performance

S Krishtul, MS Moshe, I Kovrigina, L Baruch, M Machluf - Acta Biomaterialia, 2023 - Elsevier
Microencapsulation is a promising strategy to prolong the survival and function of
transplanted pancreatic islets for diabetes therapy, albeit its translation has been impeded …

Co-transplantation of Islets-Laden Microgels and Biodegradable O2-Generating Microspheres for Diabetes Treatment

H Huang, Y Shang, H Li, Q Feng, Y Liu… - … applied materials & …, 2022 - ACS Publications
Pancreatic islets transplantation is an optimal alternative to exogenous insulin injection for
long-term effective type 1 diabetes treatment. However, direct islets transplantation without …

Immunoprotection Strategies in β‐Cell Replacement Therapy: A Closer Look at Porcine Islet Xenotransplantation

S Grimus, V Sarangova, PB Welzel, B Ludwig… - Advanced …, 2024 - Wiley Online Library
Type 1 diabetes mellitus (T1DM) is characterized by absolute insulin deficiency primarily
due to autoimmune destruction of pancreatic β‐cells. The prevailing treatment for T1DM …

Deep Learning‐Enabled Label‐Free On‐Chip Detection and Selective Extraction of Cell Aggregate‐Laden Hydrogel Microcapsules

AM White, Y Zhang, JG Shamul, J Xu, EA Kwizera… - Small, 2021 - Wiley Online Library
Microfluidic encapsulation of cells/tissues in hydrogel microcapsules has attracted
tremendous attention in the burgeoning field of cell‐based medicine. However, when …

[HTML][HTML] Probing of New Polymer-Based Microcapsules for Islet Cell Immunoisolation

P Ermakova, E Vasilchikova, M Baten'kin… - Polymers, 2024 - mdpi.com
Islet allotransplantation offers a promising cell therapy for type 1 diabetes, but challenges
such as limited donor availability and immunosuppression persist. Microencapsulation of …

An injectable and retrievable bioartificial pancreas fabricated by time-sequentially assembling islets-laden microgels for minimally invasive treatment of type 1 …

W He, H Li, X Xu, X Zhang, J Chen, C Lv, H Yu… - Chemical Engineering …, 2024 - Elsevier
Islets transplantation is a promising method to treat type 1 diabetes. Unfortunately, current
islet encapsulation and transplantation strategies are difficult to simultaneously achieve the …

Hydrogel injection molded complex macroencapsulation device geometry improves long-term cell therapy viability and function in the rat omentum transplant site

AE Emerson, Q Lyons, MW Becker, K Sepulveda… - Biomaterials, 2024 - Elsevier
Insulin-secreting allogeneic cell therapies are a promising treatment for type 1 diabetes, with
the potential to eliminate hypoglycemia and long-term complications of the disease …

Advances in single-cell nanoencapsulation and applications in diseases

Z Xue, D Mei, L Zhang - Journal of Microencapsulation, 2022 - Taylor & Francis
Single-cell nanoencapsulation is a method of coating the surface of single cell with
nanomaterials. In the early 20th century, with the introduction of various types of organic or …