The epithelial-to-mesenchymal transition (EMT) plays a critical role during normal
development and in cancer progression. EMT is induced by various signaling pathways …

Stress responses allow cells to adapt to changes in external conditions by activating specific
pathways. Here we investigate the dynamics of single cells that were subjected to acute …

Phenotypic plasticity is the ability of individual genotypes to produce different phenotypes in
response to environmental perturbations. We previously postulated how conformational …

Elucidating the design principles of regulatory networks driving cellular decision-making has
fundamental implications in mapping and eventually controlling cell-fate decisions. Despite …

Recent preclinical and clinical data suggests enhanced metastatic fitness of hybrid
epithelial/mesenchymal (E/M) phenotypes, but mechanistic details regarding their survival …

The Epithelial–mesenchymal transition (EMT) is a cellular process implicated in embryonic
development, wound healing, and pathological conditions such as cancer metastasis and …

This article introduces a special issue on the interaction between the rapidly expanding field
of machine learning and ongoing research in physics. The first half of the papers in this …

Regulatory networks as large and complex as those implicated in cell-fate choice are
expected to exhibit intricate, very high-dimensional dynamics. Cell-fate choice, however, is a …

Drug resistance is a major impediment in cancer. Although it is generally thought that
acquired drug resistance is due to genetic mutations, emerging evidence indicates that …

Phenotypic (non-genetic) heterogeneity has significant implications for the development and
evolution of organs, organisms, and populations. Recent observations in multiple cancers …