Chitin and chitosan in selected biomedical applications

A Anitha, S Sowmya, PTS Kumar, S Deepthi… - Progress in polymer …, 2014 - Elsevier
Abstract Chitin (CT), the well-known natural biopolymer and chitosan (CS)(bio-based or
“artificial polymer”) are non-toxic, biodegradable and biocompatible in nature. The …

Pathogenesis of antiphospholipid syndrome: understanding the antibodies

PL Meroni, MO Borghi, E Raschi… - Nature Reviews …, 2011 - nature.com
Antiphospholipid antibodies (aPL) are both diagnostic markers for, and pathogenic drivers
of, antiphospholipid syndrome (APS). Although the presence of aPL is a necessary pre …

[HTML][HTML] SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care

C Gutmann, K Takov, SA Burnap, B Singh, H Ali… - Nature …, 2021 - nature.com
Prognostic characteristics inform risk stratification in intensive care unit (ICU) patients with
coronavirus disease 2019 (COVID-19). We obtained blood samples (n= 474) from …

Syndecans: new kids on the signaling block

E Tkachenko, JM Rhodes, M Simons - Circulation research, 2005 - Am Heart Assoc
Cell-associated proteoglycans provide highly complex and sophisticated systems to control
interactions of extracellular cell matrix components and soluble ligands with the cell surface …

[HTML][HTML] Heparin/Heparan sulfate proteoglycans glycomic interactome in angiogenesis: biological implications and therapeutical use

P Chiodelli, A Bugatti, C Urbinati, M Rusnati - Molecules, 2015 - mdpi.com
Angiogenesis, the process of formation of new blood vessel from pre-existing ones, is
involved in various intertwined pathological processes including virus infection …

[HTML][HTML] It is time to crowd your cell culture media–physicochemical considerations with biological consequences

D Tsiapalis, DI Zeugolis - Biomaterials, 2021 - Elsevier
In vivo, the interior and exterior of cells is populated by various macromolecules that create
an extremely crowded milieu. Yet again, in vitro eukaryotic cell culture is conducted in dilute …

[HTML][HTML] Heparan sulfate proteoglycans: The sweet side of development turns sour in mucopolysaccharidoses

V De Pasquale, LM Pavone - … et Biophysica Acta (BBA)-Molecular Basis of …, 2019 - Elsevier
Heparan sulfate proteoglycans (HSPGs) are complex carbohydrate-modified proteins
ubiquitously expressed on cell surfaces, extracellular matrix and basement membrane of …

Fibroblast growth factor 2 as an antifibrotic: antagonism of myofibroblast differentiation and suppression of pro-fibrotic gene expression

DM Dolivo, SA Larson, T Dominko - Cytokine & growth factor reviews, 2017 - Elsevier
Fibrosis is a pathological condition that is characterized by the replacement of dead or
damaged tissue with a nonfunctional, mechanically aberrant scar, and fibrotic pathologies …

Heparin-functionalized chitosan–alginate scaffolds for controlled release of growth factor

YC Ho, FL Mi, HW Sung, PL Kuo - International journal of pharmaceutics, 2009 - Elsevier
Controlled long-term release of basic fibroblast growth factor (bFGF) has shown a combined
effect on the stimulation of regenerating a number of tissues including cartilage, nerve, skin …

[HTML][HTML] Adipose stem cell-derived nanovesicles inhibit emphysema primarily via an FGF2-dependent pathway

YS Kim, JY Kim, RJ Cho, DM Shin, SW Lee… - … & molecular medicine, 2017 - nature.com
Cell therapy using stem cells has produced therapeutic benefits in animal models of COPD.
Secretory mediators are proposed as one mechanism for stem cell effects because very few …