Accumulation of intracellular damage is an almost universal hallmark of aging. An improved
understanding of the systems that contribute to cellular protein quality control has shed light …

Aging is characterized by the accumulation of damage and other deleterious changes,
leading to the loss of functionality and fitness. Age-related changes occur at most levels of …

The gut microbiota evolves as the host ages, yet the effects of these microbial changes on
host physiology and energy homeostasis are poorly understood. To investigate these …

Many genes that affect replicative lifespan (RLS) in the budding yeast Saccharomyces
cerevisiae also affect aging in other organisms such as C. elegans and M. musculus. We …

Perturbed neuronal proteostasis is a salient feature shared by both aging and protein
misfolding disorders. The proteostasis network controls the health of the proteome by …

Aging constitutes the main risk factor for the development of neurodegenerative diseases.
This represents a major health issue worldwide that is only expected to escalate due to the …

Aging refers to the gradual physiological changes that occur in an organism after reaching
adulthood, resulting in senescence and a decline in biological functions, ultimately leading …

Aging and age-related neurodegeneration are both associated with the accumulation of
unfolded and abnormally folded proteins, highlighting the importance of protein homeostasis …

Mitochondria play a central role in the aging process. Studies in model organisms have
started to integrate mitochondrial effects on aging with the maintenance of protein …

Mitochondrial dysfunction is one of the primary causatives for many pathologies, including
neurodegenerative diseases, cancer, metabolic disorders, and aging. Decline in …