Background Since the 1970s, when endogenous opioids and opioid receptors were first
isolated in the central nervous system, attempts have been made to optimize opioid therapy …

Early Spinal Drug Delivery he demonstration by James Leonard Coming in 18851 that
cocaine delivered into the perispinal space would produce a state of hind-limb paralysis in …

✓ The present report details the characteristics of the analgesic effects of morphine
administered chronically by infusion pumps implanted in 53 patients suffering from terminal …

Long–term use of spinal opioids to treat chronic severe pain is widely established. However,
the indications, shortcomings and complications of the method have not been completely …

Meperidine hydrochloride is the most commonly prescribed opioid analgesic for
postoperative pain in our hospital. Biotransformation of meperidine may lead to a potentially …

This study examines the cephalad migration of morphine in CSF following lumbar epidural
administration in cancer patients with pain. Fourteen cancer patients were administered 10 …

BACKGROUND Some cancer patients require invasive techniques for control of chronic
cancer pain. Many patients have benefited from local administration of opioids and …

Acute Pain Service. Department of Anesthesiology, and College of Pharmacy, I'ain
Management Center, University of Utah Health Sciences Center, Salt Lake City, Utah p to …

Objective To assess the effect of opioid substitution (substituting one member of the opioid
class for another) on the incidence and severity of adverse effects in palliative‐care patients …

The aim of this study was to compare the incidence of technical complications of epidural
catheters with subcutaneous injection ports to percutaneous epidural catheters without …