[HTML][HTML] The C-kit receptor-mediated signal transduction and tumor-related diseases
J Liang, YL Wu, BJ Chen, W Zhang… - … journal of biological …, 2013 - ncbi.nlm.nih.gov
As an important member of tyrosine kinase family, c-kit receptor causes specific expression
of certain genes, regulates cell differentiation and proliferation, resists cell apoptosis, and …
of certain genes, regulates cell differentiation and proliferation, resists cell apoptosis, and …
Expression, mutation and copy number analysis of platelet-derived growth factor receptor A (PDGFRA) and its ligand PDGFA in gliomas
O Martinho, A Longatto-Filho, MBK Lambros… - British journal of …, 2009 - nature.com
Background: Malignant gliomas are the most prevalent type of primary brain tumours but the
therapeutic armamentarium for these tumours is limited. Platelet-derived growth factor …
therapeutic armamentarium for these tumours is limited. Platelet-derived growth factor …
Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors …
ATT De Oliveira, C Pinheiro, A Longatto-Filho… - Journal of bioenergetics …, 2012 - Springer
Monocarboxylate transporters (MCTs) have been described to play an important role in
cancer, but to date there are no reports on the significance of MCT expression in …
cancer, but to date there are no reports on the significance of MCT expression in …
Comprehensive molecular profiling of advanced/metastatic olfactory neuroblastomas
J Topcagic, R Feldman, A Ghazalpour, J Swensen… - PLoS …, 2018 - journals.plos.org
Olfactory neuroblastoma (ONB) is a rare, locally aggressive, malignant neoplasm originating
in the olfactory epithelium in the nasal vault. The recurrence rate of ONB remains high and …
in the olfactory epithelium in the nasal vault. The recurrence rate of ONB remains high and …
Gastrointestinal stromal tumors with KIT exon 9 mutations: Update on genotype-phenotype correlation and validation of a high-resolution melting assay for mutational …
H Künstlinger, S Huss… - The American Journal …, 2013 - journals.lww.com
KIT exon 9 mutations in gastrointestinal stromal tumors (GISTs) are highly relevant and have
direct therapeutic implications. In this context, we established and validated a fast and …
direct therapeutic implications. In this context, we established and validated a fast and …
Molecular characterization of EGFR, PDGFRA and VEGFR2 in cervical adenosquamous carcinoma
Background Adenosquamous carcinoma of the uterine cervix is an infrequent but
aggressive subtype of cervical cancer. A better understanding of its biological behaviour is …
aggressive subtype of cervical cancer. A better understanding of its biological behaviour is …
[HTML][HTML] Tyrosine kinase inhibitor sensitive PDGFRΑ mutations in GIST: Two cases and review of the literature
PA Boonstra, JA Gietema, AJH Suurmeijer… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Gastrointestinal stromal tumors (GISTs) are rare mesenchymal malignancies of the
gastrointestinal tract. Most GISTs harbor a c-KIT (80%) or a PDGFRα (10%) mutation that …
gastrointestinal tract. Most GISTs harbor a c-KIT (80%) or a PDGFRα (10%) mutation that …
Loss of RKIP expression is associated with poor survival in GISTs
O Martinho, A Gouveia, P Silva, A Pimenta, RM Reis… - Virchows Archiv, 2009 - Springer
Gastrointestinal stromal tumours (GISTs) are rare mesenchymal tumours of the digestive
tract and are commonly driven by oncogenic mutations in KIT and PDGFRA genes. Tumour …
tract and are commonly driven by oncogenic mutations in KIT and PDGFRA genes. Tumour …
Phase I study using crenolanib to target PDGFR kinase in children and young adults with newly diagnosed DIPG or recurrent high-grade glioma, including DIPG
CL Tinkle, A Broniscer, J Chiang… - Neuro-Oncology …, 2021 - academic.oup.com
Background Platelet-derived growth factor receptor (PDGFR) signaling has been directly
implicated in pediatric high-grade gliomagenesis. This study evaluated the safety and …
implicated in pediatric high-grade gliomagenesis. This study evaluated the safety and …
Surgical margin status and prognosis of gastrointestinal stromal tumor
AM Gouveia, AP Pimenta, AF Capelinha… - World journal of …, 2008 - Springer
Background Surgery is the best treatment for primary GIST and may be curative, but
resection extension/completeness impact on the prognosis remains controversial. The …
resection extension/completeness impact on the prognosis remains controversial. The …