Carbohydrate-binding modules: fine-tuning polysaccharide recognition

AB Boraston, DN Bolam, HJ Gilbert… - Biochemical …, 2004 - portlandpress.com
The enzymic degradation of insoluble polysaccharides is one of the most important
reactions on earth. Despite this, glycoside hydrolases attack such polysaccharides relatively …

The role of glycoconjugates as receptors for insecticidal proteins

HL Best, LJ Williamson, EA Heath… - FEMS Microbiology …, 2023 - academic.oup.com
Bacillus thuringiensis (Bt) proteins are an environmentally safe and effective alternative to
chemical pesticides and have been used as biopesticides, with great commercial success …

Understanding the biological rationale for the diversity of cellulose-directed carbohydrate-binding modules in prokaryotic enzymes

AW Blake, L McCartney, JE Flint, DN Bolam… - Journal of Biological …, 2006 - ASBMB
Plant cell walls are degraded by glycoside hydrolases that often contain noncatalytic
carbohydrate-binding modules (CBMs), which potentiate degradation. There are currently …

Three microbial strategies for plant cell wall degradation

DB Wilson - Annals of the New York Academy of Sciences, 2008 - Wiley Online Library
Cellulolytic bacteria and fungi have been shown to use two different approaches to degrade
cellulose. Most aerobic microbes secrete sets of individual cellulases, many of which contain …

Analysis of binding of the family 2a carbohydrate-binding module from Cellulomonas fimi xylanase 10A to cellulose: specificity and identification of functionally …

BW McLean, MR Bray, AB Boraston… - Protein …, 2000 - academic.oup.com
The family 2a carbohydrate-binding module (CBM2a) of xylanase 10A from Cellulomonas
fimi binds to the crystalline regions of cellulose. It does not share binding sites with the N …

Differential oligosaccharide recognition by evolutionarily-related β-1, 4 and β-1, 3 glucan-binding modules

AB Boraston, D Nurizzo, V Notenboom… - Journal of molecular …, 2002 - Elsevier
Enzymes active on complex carbohydrate polymers frequently have modular structures in
which a catalytic domain is appended to one or more carbohydrate-binding modules …

Binding affinity of family 4 carbohydrate binding module on cellulose films of nanocrystals and nanofibrils

T Liu, Y Zhang, X Lu, P Wang, X Zhang, J Tian… - Carbohydrate …, 2021 - Elsevier
The binding affinity and thermodynamics of family 4 carbohydrate-binding module (CBM4),
belonging to type B CBM, on model surfaces of cellulose nanocrystals (CNC) and nanofibrils …

Comparison of reversal activity and mechanism of action of UHRA, andexanet, and PER977 on heparin and oral FXa inhibitors

MT Kalathottukaren, AL Creagh, S Abbina… - Blood …, 2018 - ashpublications.org
Anticoagulants such as unfractionated heparin (UFH), low-molecular-weight heparins
(LMWHs), fondaparinux, and direct oral anticoagulants (DOACs) targeting thrombin (IIa) or …

Xyloglucan is recognized by carbohydrate-binding modules that interact with β-glucan chains

S Najmudin, CIPD Guerreiro, AL Carvalho… - Journal of Biological …, 2006 - ASBMB
Enzyme systems that attack the plant cell wall contain noncatalytic carbohydrate-binding
modules (CBMs) that mediate attachment to this composite structure and play a pivotal role …

Recognition and hydrolysis of noncrystalline cellulose

AB Boraston, E Kwan, P Chiu, RAJ Warren… - Journal of biological …, 2003 - ASBMB
Cellulase Cel5A from alkalophilicBacillus sp. 1139 contains a family 17 carbohydrate-
binding module (BspCBM17) and a family 28 CBM (BspCBM28) in tandem. The two …