A small number of signalling pathways are used iteratively to regulate cell fates, cell
proliferation and cell death in development. Notch is the receptor in one such pathway, and …

The modular components, or subcircuits, of developmental gene regulatory networks
(GRNs) execute specific developmental functions, such as the specification of cell identity …

Cell-type-specific transcriptional profiling often requires the isolation of specific cell types
from complex tissues. We have developed" TaDa," a technique that enables cell-specific …

During the maternal-to-zygotic transition, a developing embryo integrates post-
transcriptional regulation of maternal mRNAs with transcriptional activation of its own …

Information from developmental signaling pathways must be accurately decoded to
generate transcriptional outcomes. In the case of Notch, the intracellular domain (NICD) …

Massive zygotic transcription begins in many organisms during the midblastula transition
when the cell cycle of the dividing egg slows down. A few genes are transcribed before this …

The proper balance between symmetric and asymmetric stem cell division is crucial both to
maintain a population of stem cells and to prevent tumorous overgrowth. Neural stem cells in …

Notch signaling occurs through direct interaction between Notch, the receptor, and its
ligands, presented on the surface of neighboring cells. Endocytosis has been shown to be …

A critical juncture in early development is the partitioning of cells that will adopt different
fates into three germ layers: the ectoderm, the mesoderm, and the endoderm. This step is …

Notch signalling pathway has been implicated as an important contributor to epithelial to
myofibroblast transformation (EMT) in tumourigenesis. However, its role in kidney tubular …