Bile acids and the gut microbiota: metabolic interactions and impacts on disease

SL Collins, JG Stine, JE Bisanz, CD Okafor… - Nature Reviews …, 2023 - nature.com
Despite decades of bile acid research, diverse biological roles for bile acids have been
discovered recently due to developments in understanding the human microbiota. As …

[HTML][HTML] Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis

J Cai, L Sun, FJ Gonzalez - Cell host & microbe, 2022 - cell.com
Inflammatory bowel disease (IBD) and colorectal cancer (CRC) are heterogeneous intestinal
diseases that threaten the health of an increasing number of individuals as their lifestyles …

Hyodeoxycholic acid alleviates non-alcoholic fatty liver disease through modulating the gut-liver axis

J Kuang, J Wang, Y Li, M Li, M Zhao, K Ge, D Zheng… - Cell metabolism, 2023 - cell.com
Non-alcoholic fatty liver disease (NAFLD) is regarded as a pandemic that affects about a
quarter of the global population. Recently, host-gut microbiota metabolic interactions have …

Gut microbial metabolites as multi-kingdom intermediates

KA Krautkramer, J Fan, F Bäckhed - Nature Reviews Microbiology, 2021 - nature.com
The gut microbiota contributes to host physiology through the production of a myriad of
metabolites. These metabolites exert their effects within the host as signalling molecules and …

Bile acids as modulators of gut microbiota composition and function

AB Larabi, HLP Masson, AJ Bäumler - Gut Microbes, 2023 - Taylor & Francis
Changes in the composition of gut-associated microbial communities are associated with
many human illnesses, but the factors driving dysbiosis remain incompletely understood …

[PDF][PDF] Emerging immunotherapy for HCC: A guide for hepatologists

F Foerster, SJ Gairing, SI Ilyas, PR Galle - Hepatology, 2022 - Wiley Online Library
HCC is one of the most common cancers worldwide, and the third leading cause of cancer‐
related death globally. HCC comprises nearly 90% of all cases of primary liver cancer …

High-fat, western-style diet, systemic inflammation, and gut microbiota: a narrative review

IJ Malesza, M Malesza, J Walkowiak, N Mussin… - Cells, 2021 - mdpi.com
The gut microbiota is responsible for recovering energy from food, providing hosts with
vitamins, and providing a barrier function against exogenous pathogens. In addition, it is …

Impact of bacterial metabolites on gut barrier function and host immunity: a focus on bacterial metabolism and its relevance for intestinal inflammation

N Gasaly, P De Vos, MA Hermoso - Frontiers in immunology, 2021 - frontiersin.org
The diverse and dynamic microbial community of the human gastrointestinal tract plays a
vital role in health, with gut microbiota supporting the development and function of the gut …

Comprehensive review of targeted therapy for colorectal cancer

YH Xie, YX Chen, JY Fang - Signal transduction and targeted therapy, 2020 - nature.com
Colorectal cancer (CRC) is among the most lethal and prevalent malignancies in the world
and was responsible for nearly 881,000 cancer-related deaths in 2018. Surgery and …

Gut microbiota and Covid-19-possible link and implications

D Dhar, A Mohanty - Virus research, 2020 - Elsevier
Covid-19 is a major pandemic facing the world today caused by SARS-CoV-2 which has
implications on our understanding of infectious diseases. Although, SARS-Cov-2 primarily …