Metabolomics and type 2 diabetes risk: an updated systematic review and meta-analysis of prospective cohort studies

J Morze, C Wittenbecher, L Schwingshackl… - Diabetes …, 2022 - Am Diabetes Assoc
BACKGROUND Due to the rapidly increasing availability of metabolomics data in
prospective studies, an update of the meta evidence on metabolomics and type 2 diabetes …

Metabolomics in diabetes and diabetic complications: insights from epidemiological studies

Q Jin, RCW Ma - Cells, 2021 - mdpi.com
The increasing prevalence of diabetes and its complications, such as cardiovascular and
kidney disease, remains a huge burden globally. Identification of biomarkers for the …

Metabolomics and proteomics in type 2 diabetes

ZZ Chen, RE Gerszten - Circulation research, 2020 - Am Heart Assoc
The persistent increase in the worldwide burden of type 2 diabetes mellitus (T2D) and the
accompanying rise of its complications, including cardiovascular disease, necessitates our …

Microbiota-related metabolites and the risk of type 2 diabetes

J Vangipurapu, L Fernandes Silva, T Kuulasmaa… - Diabetes …, 2020 - Am Diabetes Assoc
OBJECTIVE Recent studies have highlighted the significance of the microbiome in human
health and disease. Changes in the metabolites produced by microbiota have been …

Predictive value of circulating NMR metabolic biomarkers for type 2 diabetes risk in the UK Biobank study

F Bragg, E Trichia, D Aguilar-Ramirez, J Bešević… - BMC medicine, 2022 - Springer
Background Effective targeted prevention of type 2 diabetes (T2D) depends on accurate
prediction of disease risk. We assessed the role of metabolomic profiling in improving T2D …

Dimethylguanidino valeric acid is a marker of liver fat and predicts diabetes

JF O'Sullivan, JE Morningstar, Q Yang… - The Journal of …, 2017 - Am Soc Clin Investig
Unbiased,“nontargeted” metabolite profiling techniques hold considerable promise for
biomarker and pathway discovery, in spite of the lack of successful applications to human …

High-coverage targeted lipidomics reveals novel serum lipid predictors and lipid pathway dysregulation antecedent to type 2 diabetes onset in normoglycemic …

J Lu, SM Lam, Q Wan, L Shi, Y Huo, L Chen… - Diabetes …, 2019 - Am Diabetes Assoc
OBJECTIVE Comprehensive assessment of serum lipidomic aberrations before type 2
diabetes mellitus (T2DM) onset has remained lacking in Han Chinese. We evaluated …

Multi-omics profiling: the way toward precision medicine in metabolic diseases

C Hu, W Jia - Journal of molecular cell biology, 2021 - academic.oup.com
Metabolic diseases including type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver
disease (NAFLD), and metabolic syndrome (MetS) are alarming health burdens around the …

[HTML][HTML] Advances in multi-omics study of biomarkers of glycolipid metabolism disorder

X Fang, R Miao, J Wei, H Wu, J Tian - Computational and Structural …, 2022 - Elsevier
Glycolipid metabolism disorder are major threats to human health and life. Genetic,
environmental, psychological, cellular, and molecular factors contribute to their …

Association of serum bile acids profile and pathway dysregulation with the risk of developing diabetes among normoglycemic Chinese adults: findings from the 4C …

J Lu, S Wang, M Li, Z Gao, Y Xu, X Zhao, C Hu… - Diabetes …, 2021 - Am Diabetes Assoc
OBJECTIVE Comprehensive assessment of serum bile acids (BAs) aberrations before
diabetes onset remains inconclusive. We examined the association of serum BA profile and …