Phytoestrogens are literally estrogenic substances of plant origin. Although these
substances are useful for plants in many aspects, their estrogenic properties are essentially …

A Hybrid drug which comprises the incorporation of two drug pharmacophores in one single
molecule are basically designed to interact with multiple targets or to amplify its effect …

Many endocrine disrupting chemicals (EDCs) adversely impact estrogen signaling by
interacting with two estrogen receptors (ERs): ERα and ERβ. Though the receptors have …

Selective estrogen receptor modulators (SERMs) are a diverse group of nonsteroidal
compounds that function as agonists or antagonists for estrogen receptors (ERs) in a target …

Protein dynamics is central to all biological processes, including signal transduction, cellular
regulation and biological catalysis. Among them, in-depth exploration of ligand-driven …

Simple Summary Estrogens, belonging to a group of steroid compounds, play an important
role in both physiological and disease processes, mainly by interacting with estrogen …

Breast cancer is the most common female malignancy and the second leading cause of
cancer related deaths. It is estimated that about 40% of all cancer in women is hormonally …

Endogenous estrogens are important regulators of cardiovascular homeostasis in
premenopausal women and delay the development of hypertension and coronary artery …

Breast cancer (BC) cell de-sensitization to Tamoxifen (TAM) or other selective estrogen
receptor (ER) modulators (SERM) is a complex process associated with BC heterogeneity …

Estrogen receptor alpha (ERα) is involved in numerous physiological and pathological
processes, including breast cancer. Breast cancer therapy is therefore currently directed at …