Biochemical and mechanical regulation of actin dynamics
Polymerization of actin filaments against membranes produces force for numerous cellular
processes, such as migration, morphogenesis, endocytosis, phagocytosis and organelle …
processes, such as migration, morphogenesis, endocytosis, phagocytosis and organelle …
Active flows and deformable surfaces in development
SC Al-Izzi, RG Morris - Seminars in Cell & Developmental Biology, 2021 - Elsevier
We review progress in active hydrodynamic descriptions of flowing media on curved and
deformable manifolds: the state-of-the-art in continuum descriptions of single-layers of …
deformable manifolds: the state-of-the-art in continuum descriptions of single-layers of …
Symmetry, thermodynamics, and topology in active matter
The name active matter refers to any collection of entities that individually use free energy to
generate their own motion and forces. Through interactions, active particles spontaneously …
generate their own motion and forces. Through interactions, active particles spontaneously …
[HTML][HTML] Establishment of a morphological atlas of the Caenorhabditis elegans embryo using deep-learning-based 4D segmentation
J Cao, G Guan, VWS Ho, MK Wong, LY Chan… - Nature …, 2020 - nature.com
The invariant development and transparent body of the nematode Caenorhabditis elegans
enables complete delineation of cell lineages throughout development. Despite extensive …
enables complete delineation of cell lineages throughout development. Despite extensive …
Dynamics and phase separation of active Brownian particles on curved surfaces and in porous media
The effect of curvature on an ensemble of repulsive active Brownian particles (ABPs) moving
on a spherical surface is studied. Surface curvature strongly affects the dynamics of ABPs …
on a spherical surface is studied. Surface curvature strongly affects the dynamics of ABPs …
[HTML][HTML] Cleavage furrow-directed cortical flows bias PAR polarization pathways to link cell polarity to cell division
During development, the conserved PAR polarity network is continuously redeployed,
requiring that it adapt to changing cellular contexts and environmental cues. In the early C …
requiring that it adapt to changing cellular contexts and environmental cues. In the early C …
A cytokinetic ring-driven cell rotation achieves Hertwig's rule in early development
TC Middelkoop, J Neipel, CE Cornell… - Proceedings of the …, 2024 - National Acad Sciences
Hertwig's rule states that cells divide along their longest axis, usually driven by forces acting
on the mitotic spindle. Here, we show that in contrast to this rule, microtubule-based pulling …
on the mitotic spindle. Here, we show that in contrast to this rule, microtubule-based pulling …
Friction patterns guide actin network contraction
The shape of cells is the outcome of the balance of inner forces produced by the actomyosin
network and the resistive forces produced by cell adhesion to their environment. The specific …
network and the resistive forces produced by cell adhesion to their environment. The specific …
[HTML][HTML] Computable early Caenorhabditis elegans embryo with a phase field model
X Kuang, G Guan, MK Wong, LY Chan… - PLOS Computational …, 2022 - journals.plos.org
Morphogenesis is a precise and robust dynamic process during metazoan embryogenesis,
consisting of both cell proliferation and cell migration. Despite the fact that much is known …
consisting of both cell proliferation and cell migration. Despite the fact that much is known …
[HTML][HTML] Stability of asymmetric cell division: A deformable cell model of cytokinesis applied to C. elegans
M Cuvelier, J Vangheel, W Thiels, H Ramon, R Jelier… - Biophysical …, 2023 - cell.com
Cell division during early embryogenesis is linked to key morphogenic events such as
embryo symmetry breaking and tissue patterning. It is thought that the physical surrounding …
embryo symmetry breaking and tissue patterning. It is thought that the physical surrounding …