Structural basis for ion selectivity in potassium-selective channelrhodopsins
KCR channelrhodopsins (K+-selective light-gated ion channels) have received attention as
potential inhibitory optogenetic tools but more broadly pose a fundamental mystery …
potential inhibitory optogenetic tools but more broadly pose a fundamental mystery …
Structural foundations of potassium selectivity in channelrhodopsins
EG Govorunova, OA Sineshchekov, LS Brown… - MBio, 2022 - Am Soc Microbiol
Potassium-selective channelrhodopsins (KCRs) are light-gated K+ channels recently found
in the stramenopile protist Hyphochytrium catenoides. When expressed in neurons, KCRs …
in the stramenopile protist Hyphochytrium catenoides. When expressed in neurons, KCRs …
Robust Optogenetic Inhibition with Red-light-sensitive Anion-conducting Channelrhodopsins
J Oppermann, A Rozenberg, T Fabrin… - bioRxiv, 2023 - biorxiv.org
Channelrhodopsins (ChRs) are light-gated ion channels that are widely used to optically
activate or silence electrogenic cells such as neurons. Here, we describe the identification …
activate or silence electrogenic cells such as neurons. Here, we describe the identification …