Cellular membranes can form two principally different involutions, which either exclude or
contain cytosol. The 'classical'budding reactions, such as those occurring during …

Maintenance of plasma membrane integrity is essential for normal cell viability and function.
Thus, robust membrane repair mechanisms have evolved to counteract the eminent threat of …

Mycobacterium tuberculosis is a global health problem in part as a result of extensive
cytotoxicity caused by the infection. Here, we show how M. tuberculosis causes caspase …

The compartmentalization of eukaryotic cells, which is essential for their viability and
functions, is ensured by single or double bilayer membranes that separate the cell from the …

Membrane remodeling and repair are essential for all cells. Proteins that perform these
functions include Vipp1/IM30 in photosynthetic plastids, PspA in bacteria, and ESCRT-III in …

The plasma membrane is made of glycerophospholipids that separate the inner and outer
parts of the cell. Under physiological conditions, it acts as a barrier and gatekeeper to protect …

The plasma membrane shapes and protects the eukaryotic cell from its surroundings and is
crucial for cell life. Although initial repair mechanisms to reseal injured membranes are well …

Annexins are cytosolic proteins with conserved three-dimensional structures that bind acidic
phospholipids in cellular membranes at elevated Ca2+ levels. Through this they act as Ca2+ …

The ESCRT machinery is an evolutionarily conserved membrane remodeling complex that
is used by the cell to perform reverse membrane scission in essential processes like protein …

Plasma membrane integrity is essential for cellular homeostasis. In vivo, cells experience
plasma membrane damage from a multitude of stressors in the extra-and intra-cellular …