Polymers that release functional small molecules under mechanical stress potentially serve
as next-generation materials for catalysis, sensing, and mechanochemical dynamic therapy …

The ball-mill grinding (BMG) of polymers has a long history, starting with Staudinger
showing in the 1930s that polystyrene undergoes chain scission upon ball milling. However …

Active pharmaceutical ingredients are the most consequential and widely employed
treatment in medicine although they suffer from many systematic limitations, particularly off …

Stimulus-responsive gating of chemical reactions is of considerable practical and
conceptual interest. For example, photocleavable protective groups and gating …

Polymers that release small molecules in response to mechanical force are promising for a
variety of applications including drug delivery, catalysis, and sensing. While a number of …

Gasotransmitters like nitric oxide, carbon monoxide, and hydrogen sulfide with unique
pleiotropic pharmacological effects in mammals are an emerging therapeutic modality for …

Mechanoluminescence, or the generation of light from materials under external force, is a
powerful tool for biology and materials science. However, direct mechanoluminescence from …

Force-controlled release of small molecules offers great promise for the delivery of drugs
and the release of healing or reporting agents in a medical or materials context,–. In polymer …

Mechanophores (mechanosensitive molecules) have been instrumental in the development
of various force-controlled release systems. However, the release of functional organic …

A series of monodisperse cyclic and linear poly (d, l-lactide) s (c-PLA and l-PLA,
respectively) were prepared with various degrees of polymerization (DP) using an iterative …