The Netrin-1/DCC guidance system: dopamine pathway maturation and psychiatric disorders emerging in adolescence
Axon guidance molecules direct growing axons toward their targets, assembling the intricate
wiring of the nervous system. One of these molecules, Netrin-1, and its receptor, DCC …
wiring of the nervous system. One of these molecules, Netrin-1, and its receptor, DCC …
Mechanistic advances in axon pathfinding
LE McCormick, SL Gupton - Current opinion in cell biology, 2020 - Elsevier
The development of a functional nervous system entails establishing connectivity between
appropriate synaptic partners. During axonal pathfinding, the developing axon navigates …
appropriate synaptic partners. During axonal pathfinding, the developing axon navigates …
Approaches and limitations in the investigation of synaptic transmission and plasticity
SD Glasgow, R McPhedrain, JF Madranges… - Frontiers in synaptic …, 2019 - frontiersin.org
The numbers and strengths of synapses in the brain change throughout development, and
even into adulthood, as synaptic inputs are added, eliminated, and refined in response to …
even into adulthood, as synaptic inputs are added, eliminated, and refined in response to …
Adamtsl3 mediates DCC signaling to selectively promote GABAergic synapse function
TML Cramer, B Pinan-Lucarre, A Cavaccini, A Damilou… - Cell Reports, 2023 - cell.com
The molecular code that controls synapse formation and maintenance in vivo has remained
quite sparse. Here, we identify that the secreted protein Adamtsl3 functions as critical …
quite sparse. Here, we identify that the secreted protein Adamtsl3 functions as critical …
Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions
Chronic pain is often present at more than one anatomical location, leading to chronic
overlapping pain conditions. Whether chronic overlapping pain conditions represent a …
overlapping pain conditions. Whether chronic overlapping pain conditions represent a …
The Netrin-1/DCC guidance cue pathway as a molecular target in depression: translational evidence
The Netrin-1/DCC guidance cue pathway plays a critical role in guiding growing axons
toward the prefrontal cortex during adolescence and in the maturational organization and …
toward the prefrontal cortex during adolescence and in the maturational organization and …
Schizophrenia-derived hiPSC brain microvascular endothelial-like cells show impairments in angiogenesis and blood–brain barrier function
Schizophrenia (SZ) is a complex neuropsychiatric disorder, affecting 1% of the world
population. Long-standing clinical observations and molecular data have pointed to a …
population. Long-standing clinical observations and molecular data have pointed to a …
Guiding synaptic plasticity: novel roles for netrin‐1 in synaptic plasticity and memory formation in the adult brain
SD Glasgow, ES Ruthazer… - The Journal of …, 2021 - Wiley Online Library
Adult neural plasticity engages mechanisms that change synapse structure and function, yet
many of the underlying events bear a striking similarity to processes that occur during the …
many of the underlying events bear a striking similarity to processes that occur during the …
[HTML][HTML] Metabotropic actions of kainate receptors modulating glutamate release
R Falcón-Moya, A Rodríguez-Moreno - Neuropharmacology, 2021 - Elsevier
Presynaptic kainate (KA) receptors (KARs) modulate GABA and glutamate release in the
central nervous system of mammals. While some of the actions of KARs are ionotropic …
central nervous system of mammals. While some of the actions of KARs are ionotropic …
Netrin-1 regulates the balance of synaptic glutamate signaling in the adult ventral tegmental area
MM Cline, B Juarez, A Hunker, EG Regiarto, B Hariadi… - Elife, 2023 - elifesciences.org
The axonal guidance cue netrin-1 serves a critical role in neural circuit development by
promoting growth cone motility, axonal branching, and synaptogenesis. Within the adult …
promoting growth cone motility, axonal branching, and synaptogenesis. Within the adult …