The early observations on the rate-of-living theory by Max Rubner and the report by
Gershman that oxygen free radicals exist in vivo culminated in the seminal proposal in the …

There are many mechanisms of lifespan extension, including the disruption of insulin/insulin-
like growth factor 1 (IGF-1) signaling, metabolism, translation, and feeding. Despite the …

Abstract Background In the nematode Caenorhabditis elegans the conserved Ins/IGF-1
signaling pathway regulates many biological processes including life span, stress response …

The molecular response of animals to nanoplastic particles is still largely unclear. In this
study, we employed a modified prolonged exposure system to investigate the molecular …

During normal development or during disease, animal cells experience hypoxic (low
oxygen) conditions, and the hypoxia-inducible factor (HIF) transcription factors implement …

This Review discusses the potential usefulness of the worm Caenorhabditis elegans as a
model organism for chemists interested in studying living systems. C. elegans, a 1 mm long …

All organisms live in temporally fluctuating environments. Theory predicts that the evolution
of deterministic maternal effects (ie, anticipatory maternal effects or transgenerational …

Oxygen deprivation is rapidly deleterious for most organisms. However, Caenorhabditis
elegans has developed the ability to survive anoxia for at least 48 hours. Mutations in the …

Caenorhabditis elegans has orthologs for most of the key enzymes involved in eukaryotic
intermediary metabolism, suggesting that the major metabolic pathways are probably …

In normal development and homeostasis and in many disease states, cells and tissues must
overcome the challenge of oxygen deprivation (hypoxia). The nematode C. elegans is …