Objective The aim of the study was to investigate how doctors considered and experienced
the concept of equipoise while recruiting patients to randomized controlled trials (RCTs) …

It has historically been very difficult to conduct early phase drug studies in children for a
number of reasons related to ethics, acceptability, rarity, standardization, end points, safety …

Background One of the most difficult aspects of conducting clinical research is the ability to
successfully recruit participants. Pediatric clinical research presents unique recruitment …

Background Randomised controlled trials are widely established as the best method for
testing health interventions whilst minimising bias. However, recruitment and subsequent …

Objective Running randomized clinical trials (RCT) in fetal therapy is challenging. This is no
different for fetoscopic endoluminal tracheal occlusion (FETO) for severe left‐sided …

Participant recruitment for pediatric palliative intervention studies is a chronic challenge for
researchers. Digital recruitment strategies, or digital technology-assisted recruitment …

Effective participant recruitment is a critical challenge in clinical trials. Inadequate enrollment
of participants can precipitate delays, escalated costs, and compromise scientific integrity …

Background Although detection of children at high risk of developing type 1 diabetes and
diagnosis of early stages is possible, up to now there exists no approved therapy to delay or …

Our objective was to examine patients' health behaviors and the related practices of their
primary-care physicians to determine whether physicians' actions might help to reduce the …

Background Recruitment of pediatric participants in studies is difficult due to the vulnerability
of this population and the scarcity of certain conditions. Co-enrolling in multiple studies is a …