Living organisms are continuously exposed to a myriad of DNA damaging agents that can
impact health and modulate disease‐states. However, robust DNA repair and damage …

The routine and often unavoidable exposure to solar ultraviolet (UV) radiation makes it one
of the most significant environmental DNA-damaging agents to which humans are exposed …

The accurate copying of genetic information in the double helix of DNA is essential for
inheritance of traits that define the phenotype of cells and the organism. The core …

Commonly consumed foods and beverages can contain chemicals with reported
carcinogenic activity in rodent models. Moreover, exposures to some of these substances …

Rationale: To study the relationship between emphysema and/or airflow obstruction and
lung cancer in a high-risk population. Objective: We studied lung cancer related to …

Polκ and Rev1 are members of the Y family of DNA polymerases involved in tolerance to
DNA damage by replicative bypass [translesion DNA synthesis (TLS)]. We demonstrate that …

Living organisms are continually under attack from a vast array of DNA-damaging agents
that imperils their genomic integrity. As a consequence, cells posses an army of enzymes to …

DNA double‐strand breaks (DSBs) represent dangerous chromosomal lesions that can lead
to mutation, neoplastic transformation, or cell death. DSBs can occur by extrinsic insult from …

The replicative bypass of base damage in DNA (translesion DNA synthesis [TLS]) is a
ubiquitous mechanism for relieving arrested DNA replication. The process requires multiple …

When cells that are actively replicating DNA encounter sites of base damage or strand
breaks, replication might stall or arrest. In this situation, cells rely on DNA-damage-tolerance …