Sex hormone signaling and regulation of immune function
Immune responses to antigens, including innocuous, self, tumor, microbial, and vaccine
antigens, differ between males and females. The quest to uncover the mechanisms for …
antigens, differ between males and females. The quest to uncover the mechanisms for …
Biased signalling: from simple switches to allosteric microprocessors
G protein-coupled receptors (GPCRs) are the largest class of receptors in the human
genome and some of the most common drug targets. It is now well established that GPCRs …
genome and some of the most common drug targets. It is now well established that GPCRs …
The nuclear receptor superfamily: A structural perspective
ER Weikum, X Liu, EA Ortlund - Protein Science, 2018 - Wiley Online Library
Nuclear receptors (NRs) are a family of transcription factors that regulate numerous
physiological processes such as metabolism, reproduction, inflammation, as well as the …
physiological processes such as metabolism, reproduction, inflammation, as well as the …
Induced protein degradation: an emerging drug discovery paradigm
Small-molecule drug discovery has traditionally focused on occupancy of a binding site that
directly affects protein function, and this approach typically precludes targeting proteins that …
directly affects protein function, and this approach typically precludes targeting proteins that …
[HTML][HTML] Selective estrogen receptor modulators (SERMs) and selective estrogen receptor degraders (SERDs) in cancer treatment
HK Patel, T Bihani - Pharmacology & therapeutics, 2018 - Elsevier
Breast cancer is the most frequently diagnosed cancer in women, with estrogen receptor
positive (ER+) breast cancer making up approximately 75% of all breast cancers diagnosed …
positive (ER+) breast cancer making up approximately 75% of all breast cancers diagnosed …
Effect of estrogen on musculoskeletal performance and injury risk
N Chidi-Ogbolu, K Baar - Frontiers in physiology, 2019 - frontiersin.org
Estrogen has a dramatic effect on musculoskeletal function. Beyond the known relationship
between estrogen and bone, it directly affects the structure and function of other …
between estrogen and bone, it directly affects the structure and function of other …
Sex and gender differences in bacterial infections
SP Dias, MC Brouwer, D van de Beek - Infection and Immunity, 2022 - Am Soc Microbiol
There is a growing awareness of the importance of sex and gender in medicine and
research. Women typically have stronger immune responses to self and foreign antigens …
research. Women typically have stronger immune responses to self and foreign antigens …
Molecular mechanism of estrogen–estrogen receptor signaling
Abstract 17β‐Estradiol (E2), as the main circulating estrogen hormone, regulates many
tissue and organ functions in physiology. The effects of E2 on cells are mediated by the …
tissue and organ functions in physiology. The effects of E2 on cells are mediated by the …
Estrogen receptors regulate innate immune cells and signaling pathways
S Kovats - Cellular immunology, 2015 - Elsevier
Humans show strong sex differences in immunity to infection and autoimmunity, suggesting
sex hormones modulate immune responses. Indeed, receptors for estrogens (ERs) regulate …
sex hormones modulate immune responses. Indeed, receptors for estrogens (ERs) regulate …
Trauma-induced coagulopathy
Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …