BiP and its nucleotide exchange factors Grp170 and Sil1: mechanisms of action and biological functions
BiP (immunoglobulin heavy-chain binding p rotein) is the endoplasmic reticulum (ER)
orthologue of the Hsp70 family of molecular chaperones and is intricately involved in most …
orthologue of the Hsp70 family of molecular chaperones and is intricately involved in most …
Unveiling the dark side of glucose-regulated protein 78 (GRP78) in cancers and other human pathology: A systematic review
AO Akinyemi, KE Simpson, SF Oyelere, M Nur… - Molecular …, 2023 - Springer
Abstract Glucose-Regulated Protein 78 (GRP78) is a chaperone protein that is
predominantly expressed in the lumen of the endoplasmic reticulum. GRP78 plays a crucial …
predominantly expressed in the lumen of the endoplasmic reticulum. GRP78 plays a crucial …
Polystyrene nanoparticles affect the innate immune system of the Antarctic sea urchin Sterechinus neumayeri
E Bergami, A Krupinski Emerenciano… - Polar Biology, 2019 - Springer
Plastic debris has been recognised as a potential stressor for Antarctic marine organisms. In
this study, the effects of surface charged polystyrene nanoparticles (PS NPs) on the immune …
this study, the effects of surface charged polystyrene nanoparticles (PS NPs) on the immune …
The HSP immune network in cancer
Z Albakova, Y Mangasarova - Frontiers in immunology, 2021 - frontiersin.org
Heat shock proteins are molecular chaperones which support tumor development by
regulating various cellular processes including unfolded protein response, mitochondrial …
regulating various cellular processes including unfolded protein response, mitochondrial …
Unfolding the role of large heat shock proteins: new insights and therapeutic implications
D Zuo, J Subjeck, XY Wang - Frontiers in immunology, 2016 - frontiersin.org
Heat shock proteins (HSPs) of eukaryotes are evolutionarily conserved molecules present in
all the major intracellular organelles. They mainly function as molecular chaperones and …
all the major intracellular organelles. They mainly function as molecular chaperones and …
Biological function of HYOU1 in tumors and other diseases
S Rao, L Oyang, J Liang, P Yi, Y Han, X Luo… - OncoTargets and …, 2021 - Taylor & Francis
Various stimuli induce an unfolded protein response to endoplasmic reticulum stress,
accompanied by the expression of endoplasmic reticulum molecular chaperones. Hypoxia …
accompanied by the expression of endoplasmic reticulum molecular chaperones. Hypoxia …
The multiple roles and therapeutic potential of molecular chaperones in prostate cancer
Prostate cancer (PCa) is one of the most common cancer types in men worldwide. Heat
shock proteins (HSPs) are molecular chaperones that are widely implicated in the …
shock proteins (HSPs) are molecular chaperones that are widely implicated in the …
Juvenile hormone differentially regulates two Grp78 genes encoding protein chaperones required for insect fat body cell homeostasis and vitellogenesis
Juvenile hormone (JH) has a well known role in stimulating insect vitellogenesis (ie yolk
deposition) and oocyte maturation, but the molecular mechanisms of JH action in insect …
deposition) and oocyte maturation, but the molecular mechanisms of JH action in insect …
Protein aggregates and aggrephagy in myopathies
S Gibertini, A Ruggieri, M Cheli, L Maggi - International journal of …, 2023 - mdpi.com
A number of muscular disorders are hallmarked by the aggregation of misfolded proteins
within muscle fibers. A specialized form of macroautophagy, termed aggrephagy, is …
within muscle fibers. A specialized form of macroautophagy, termed aggrephagy, is …
[HTML][HTML] Immunologically programming the tumor microenvironment induces the pattern recognition receptor NLRC4-dependent antitumor immunity
Background The efficacy of cancer immunotherapy can be limited by the poor
immunogenicity of cancer and the immunosuppressive tumor microenvironment (TME) …
immunogenicity of cancer and the immunosuppressive tumor microenvironment (TME) …