These updated guidelines are based on the first edition of the World Federation of Societies
of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia …

HIV is a virus that remains a major health concern and results in an infection that has no
cure even after over 30 years since its discovery. As such, HIV vaccine discovery continues …

Objective: The efficacy of therapeutic vaccines against HIV-1 infection has been modest.
New inerts to redirect responses to vulnerable sites are urgently needed to improve these …

Highlights•New progress has been made in understanding effective protective mechanisms
of anti-HIV CD8 cytolytic T lymphocytes.•New progress has been made in understanding the …

Immunogenicity of HIV-1 mRNA vaccine regimens was analyzed in a non-human primate
animal model. Rhesus macaques immunized with mRNA in lipid nanoparticle (mRNA/LNP) …

Background None of the HIV T-cell vaccine candidates that have reached advanced clinical
testing have been able to induce protective T cell immunity. A major reason for these failures …

Background Strong and broad antiviral T-cell responses targeting vulnerable sites of HIV-1
will likely be a critical component for any effective cure strategy. Methods BCN01 trial was a …

Recently discovered Clustered Regularly Interspaced Short Palindromic Repeats
(CRISPR)/Cas13 proteins are programmable RNA-guided ribonucleases that target single …

An effective human immunodeficiency virus type 1 (HIV-1) vaccine is expected to have the
greatest impact on HIV-1 spread and remains a global scientific priority. Only one candidate …

Therapeutic vaccinations aim to re-educate human immunodeficiency virus (HIV)-1-specific
immune responses to achieve durable control of HIV-1 replication in virally suppressed …