Neuroimmune mechanisms and therapies mediating post-ischaemic brain injury and repair

T Shichita, H Ooboshi, A Yoshimura - Nature Reviews Neuroscience, 2023 - nature.com
The nervous and immune systems control whole-body homeostasis and respond to various
types of tissue injury, including stroke, in a coordinated manner. Cerebral ischaemia and …

Impact of mobile stroke units

K Fassbender, F Merzou, M Lesmeister… - Journal of Neurology …, 2021 - jnnp.bmj.com
Since its first introduction in clinical practice in 2008, the concept of mobile stroke unit
enabling prehospital stroke treatment has rapidly expanded worldwide. This review …

Identifying best practices to improve evaluation and management of in-hospital stroke: a scientific statement from the American Heart Association

A Nouh, S Amin-Hanjani, KL Furie, WN Kernan… - Stroke, 2022 - Am Heart Assoc
This scientific statement describes a path to optimizing care for patients who experience an
in-hospital stroke. Although these patients are in a monitored environment, their evaluation …

Progresses and prospects of neuroprotective agents-loaded nanoparticles and biomimetic material in ischemic stroke

J Chen, J Jin, K Li, L Shi, X Wen, F Fang - Frontiers in Cellular …, 2022 - frontiersin.org
Ischemic stroke remains the leading cause of death and disability, while the main
mechanisms of dominant neurological damage in stroke contain excitotoxicity, oxidative …

Shorter door-to-needle times are associated with better outcomes after intravenous thrombolytic therapy and endovascular thrombectomy for acute ischemic stroke

S Man, N Solomon, B Mac Grory, B Alhanti, K Uchino… - Circulation, 2023 - Am Heart Assoc
Background: Existing data and clinical trials could not determine whether faster intravenous
thrombolytic therapy (IVT) translates into better long-term functional outcomes after acute …

Fluorescent Probe for Investigating the Mitochondrial Viscosity and Hydrogen Peroxide Changes in Cerebral Ischemia/Reperfusion Injury

C Fang, Q Deng, K Zhao, Z Zhou, X Zhu, F Liu… - Analytical …, 2024 - ACS Publications
Cerebral ischemia–reperfusion injury (CIRI), a cause of cerebral dysfunction during cerebral
infarction treatment, is closely associated with mitochondrial viscosity and hydrogen …

An ultrasensitive fluorescent platform for monitoring GSH variation during ischemic stroke

X Xiong, Y Ye, X Gao, H Zhu, W Hu, C Li, Z Jian… - Chemical Engineering …, 2022 - Elsevier
The growing evidence suggests that the disturbance of redox homeostasis in the brain
tissue contributes to the process of tissue damage following ischemic stroke (IS). Tracking …

Phase I trial outcome of amnion cell therapy in patients with ischemic stroke (I-ACT)

TG Phan, R Lim, ST Chan, H McDonald… - Frontiers in …, 2023 - frontiersin.org
Background We proposed a Phase I dose escalation trial to assess the safety of allogeneic
human amniotic epithelial cells (hAECs) in stroke patients with a view to informing the …

Bridging thrombolysis in atrial fibrillation stroke is associated with increased hemorrhagic complications without improved outcomes

F Akbik, A Alawieh, L Dimisko, BM Howard… - Journal of …, 2022 - jnis.bmj.com
Background Atrial fibrillation (AF) associated ischemic stroke is associated with worse
functional outcomes, less effective recanalization, and increased rates of hemorrhagic …

Effectiveness and safety of EVT in patients with acute LVO and low NIHSS

BJ Kim, BK Menon, J Yoo, JH Han, BJ Kim… - Frontiers in …, 2022 - frontiersin.org
Background and purpose There is much uncertainty in endovascular treatment (EVT)
decisions in patients with acute large vessel occlusion (LVO) and mild neurological deficits …