The functional properties of molecular systems are generally determined by the sum of many
weak non-covalent interactions, and therefore methods for predicting the relative …

Mechanochemistry is considered an alternative attractive greener approach to prepare
diverse molecular compounds and has become an important synthetic tool in different fields …

Computational chemistry applications have become an integral part of the drug discovery
workflow over the past 35 years. However, computational modeling in support of drug …

Experimental mechanochemical screening of cocrystals with linezolid (LIN) resulted in the
formation of six new crystal phases, including three neat cocrystals and three cocrystal …

In this study, the existing set of carbamazepine (CBZ) cocrystals was extended through the
successful combination of the drug with the positional isomers of acetamidobenzoic acid …

Co-crystal formation can improve the physicochemical properties of a compound, thus
enhancing its druggability. Therefore, artificial intelligence-based co-crystal virtual screening …

Cancer ranks as the second foremost cause of death in various corners of the globe. The
clinical uses of assorted anticancer therapeutics have been limited owing to the poor …

Pharmaceutical cocrystals represent a distinctive class of crystal engineered
multicomponent systems consisting an API and a crystal former non-covalently linked …

Based on the review of the literature results the database of the fusion temperatures of two-
component molecular crystals (1947 co-crystals) and individual components thereof was …

Cocrystal engineering for bioavailability enhancement is still a serendipitous process, which
requires systematic solution crystallization, in vivo predictive dissolution, and …