Contrary to the long-held view that most humans harbour only identical mitochondrial
genomes, deep resequencing has uncovered unanticipated extreme genetic variation within …

Epigenetic regulation of mitochondrial DNA (mtDNA) is an emerging and fast-developing
field of research. Compared to regulation of nucler DNA, mechanisms of mtDNA epigenetic …

Epigenetic modifications of the nuclear genome, including DNA methylation, histone
modifications and non-coding RNA post-transcriptional regulation, are increasingly being …

Maintenance of the mitochondrial genome is essential for proper cellular function. For this
purpose, mitochondrial DNA (mtDNA) needs to be faithfully replicated, transcribed …

Mitochondria are controlled by the coordination of two genomes: the mitochondrial and the
nuclear DNA. As such, variations in nuclear gene expression as a consequence of …

Mitochondrial dysfunction plays critical roles in cancer development and related therapeutic
response; however, exact molecular mechanisms remain unclear. Recently, alongside the …

Insulin resistance (IR), a key component of the metabolic syndrome, precedes the
development of diabetes, cardiovascular disease, and Alzheimer's disease. Its etiological …

Cellular senescence is a complex cell fate response that is thought to underlie several age-
related pathologies. Despite a loss of proliferative potential, senescent cells are …

The mitochondrial genome (mtDNA) represents a tiny fraction of the whole genome,
comprising just 16.6 kilobases encoding 37 genes involved in oxidative phosphorylation …

How individual genes are regulated from a mitochondrial polycistronic transcript to have
variable expression remains an enigma. Here, through bisulfite sequencing and strand …