Exosomes derived from 3D-cultured MSCs improve therapeutic effects in periodontitis and experimental colitis and restore the Th17 cell/Treg balance in inflamed …
Y Zhang, J Chen, H Fu, S Kuang, F He… - International journal of …, 2021 - nature.com
Although mesenchymal stem cell-derived exosomes (MSC-exos) have been shown to have
therapeutic effects in experimental periodontitis, their drawbacks, such as low yield and …
therapeutic effects in experimental periodontitis, their drawbacks, such as low yield and …
Opposing roles of wild-type and mutant p53 in the process of epithelial to mesenchymal transition
O Semenov, A Daks, O Fedorova… - Frontiers in Molecular …, 2022 - frontiersin.org
The central role of an aberrantly activated EMT program in defining the critical features of
aggressive carcinomas is well documented and includes cell plasticity, metastatic …
aggressive carcinomas is well documented and includes cell plasticity, metastatic …
p53-dependent and-independent epithelial integrity: beyond miRNAs and metabolic fluctuations
T Oikawa, Y Otsuka, H Sabe - Cancers, 2018 - mdpi.com
In addition to its classical roles as a tumor suppressor, p53 has also been shown to act as a
guardian of epithelial integrity by inducing the microRNAs that target transcriptional factors …
guardian of epithelial integrity by inducing the microRNAs that target transcriptional factors …
Genetic and Epigenetic Alterations of CDH1 Regulatory Regions in Hereditary and Sporadic Gastric Cancer
E-cadherin is a key player in gastric cancer (GC) and germline alterations of CDH1, its
encoding gene, are responsible for Hereditary Diffuse Gastric Cancer (HDGC) syndrome …
encoding gene, are responsible for Hereditary Diffuse Gastric Cancer (HDGC) syndrome …
AKT1 E17K inhibits cancer cell migration by abrogating β-catenin signaling
Mutational activation of the PI3K/AKT pathway is among the most common pro-oncogenic
events in human cancers. The clinical utility of PI3K and AKT inhibitors has, however, been …
events in human cancers. The clinical utility of PI3K and AKT inhibitors has, however, been …
Integrated Multiomics Reveals Silencing of has_circ_0006646 Promotes TRIM21‐Mediated NCL Ubiquitination to Inhibit Hepatocellular Carcinoma Metastasis
X Hu, G Chen, Y Huang, Q Cheng, J Zhuo… - Advanced …, 2024 - Wiley Online Library
Recent studies suggest that circular RNA (circRNA)‐mediated post‐translational
modification of RNA‐binding proteins (RBP) plays a pivotal role in metastasis of …
modification of RNA‐binding proteins (RBP) plays a pivotal role in metastasis of …
Early secreted antigenic target of 6-kDa of Mycobacterium tuberculosis induces transition of macrophages into epithelioid macrophages by downregulating iNOS/NO …
J Lin, Y Jiang, D Liu, X Dai, M Wang, Y Dai - Molecular immunology, 2020 - Elsevier
Background Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium
tuberculosis (Mtb). Granuloma is a pathological feature of tuberculosis and is a tight immune …
tuberculosis (Mtb). Granuloma is a pathological feature of tuberculosis and is a tight immune …
Inactivation of homeodomain‐interacting protein kinase 2 promotes oral squamous cell carcinoma metastasis through inhibition of P53‐dependent E‐cadherin …
X Zheng, Y Pan, X Chen, S Xia, Y Hu, Y Zhou… - Cancer …, 2021 - Wiley Online Library
Homeodomain‐interacting protein kinase 2 (HIPK2), a well‐known tumor suppressor, shows
contradictory expression patterns in different cancers. This study was undertaken to clarify …
contradictory expression patterns in different cancers. This study was undertaken to clarify …
p53 ensures the normal behavior and modification of G1/S-specific histone H3. 1 in the nucleus
H3. 1 histone is predominantly synthesized and enters the nucleus during the G1/S phase of
the cell cycle, as a new component of duplicating nucleosomes. Here, we found that p53 is …
the cell cycle, as a new component of duplicating nucleosomes. Here, we found that p53 is …
Regulation of male germline transmission patterns by the Trp53-Cdkn1a pathway
M Kanatsu-Shinohara, H Naoki, T Tanaka, M Tatehana… - Stem Cell Reports, 2022 - cell.com
A small number of offspring are born from the numerous sperm generated from
spermatogonial stem cells (SSCs). However, little is known regarding the rules and …
spermatogonial stem cells (SSCs). However, little is known regarding the rules and …