Locoregional therapies in the era of molecular and immune treatments for hepatocellular carcinoma

JM Llovet, T De Baere, L Kulik, PK Haber… - Nature reviews …, 2021 - nature.com
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related mortality and
has an increasing incidence worldwide. Locoregional therapies, defined as imaging-guided …

Thermal ablation of tumours: biological mechanisms and advances in therapy

KF Chu, DE Dupuy - Nature Reviews Cancer, 2014 - nature.com
Minimally invasive thermal ablation of tumours has become common since the advent of
modern imaging. From the ablation of small, unresectable tumours to experimental …

Thermal and mechanical high-intensity focused ultrasound: perspectives on tumor ablation, immune effects and combination strategies

RJE van den Bijgaart, DC Eikelenboom… - Cancer Immunology …, 2017 - Springer
Tumor ablation technologies, such as radiofrequency-, cryo-or high-intensity focused
ultrasound (HIFU) ablation will destroy tumor tissue in a minimally invasive manner. Ablation …

Microwave ablation enhances tumor-specific immune response in patients with hepatocellular carcinoma

K Leuchte, E Staib, M Thelen, P Gödel… - Cancer Immunology …, 2021 - Springer
Thermal ablative therapies are standard treatments for localized hepatocellular carcinoma
(HCC). In addition to local tumor destruction, ablation leads to abscopal effects in distant …

More than just tumor destruction: immunomodulation by thermal ablation of cancer

SP Haen, PL Pereira, HR Salih… - Journal of …, 2011 - Wiley Online Library
Over the past decades, thermoablative techniques for the therapy of localized tumors have
gained importance in the treatment of patients not eligible for surgical resection. Anecdotal …

Thermal ablative therapies and immune checkpoint modulation: can locoregional approaches effect a systemic response?

A Mehta, R Oklu, RA Sheth - Gastroenterology research and …, 2016 - Wiley Online Library
Percutaneous image‐guided ablation is an increasingly common treatment for a multitude of
solid organ malignancies. While historically these techniques have been restricted to the …

Interventional oncologic approaches to liver metastases

AH Mahnken, PL Pereira, T de Baère - Radiology, 2013 - pubs.rsna.org
Metastatic liver disease is the most common cause of death in cancer patients. Complete
surgical resection is currently considered the only curative treatment, with only about 25% of …

Recent advances in tumor ablation for hepatocellular carcinoma

TW Kang, H Rhim - Liver Cancer, 2015 - karger.com
Image-guided tumor ablation for early stage hepatocellular carcinoma (HCC) is an accepted
non-surgical treatment that provides excellent local tumor control and favorable survival …

Immunomodulatory effect after irreversible electroporation in patients with locally advanced pancreatic cancer

C He, J Wang, S Sun, Y Zhang, S Li - Journal of oncology, 2019 - Wiley Online Library
Purpose. Irreversible electroporation (IRE) has been demonstrated to be a safe and effective
method for locally advanced pancreatic cancer (LAPC). The aim of this study was to …

Friend or foe? Locoregional therapies and immunotherapies in the current hepatocellular treatment landscape

S Young, J Hannallah, D Goldberg, T Sanghvi… - International Journal of …, 2023 - mdpi.com
Over the last several decades, a number of new treatment options for patients with
hepatocellular carcinoma (HCC) have been developed. While treatment decisions for some …