Neurophysiology of HCN channels: from cellular functions to multiple regulations
C He, F Chen, B Li, Z Hu - Progress in neurobiology, 2014 - Elsevier
Highlights•Hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels are
involved in multiple physiological processes.•HCN channels are excellent targets of various …
involved in multiple physiological processes.•HCN channels are excellent targets of various …
How can we identify ictal and interictal abnormal activity?
RS Fisher, HE Scharfman, M DeCurtis - … in clinical epileptology: A view from …, 2014 - Springer
Abstract The International League Against Epilepsy (ILAE) defined a seizure as “a transient
occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal …
occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal …
HCN channels: function and clinical implications
EE Benarroch - Neurology, 2013 - AAN Enterprises
The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels belong to the
superfamily of pore-loop cation channels. In mammals, the HCN channel family comprises 4 …
superfamily of pore-loop cation channels. In mammals, the HCN channel family comprises 4 …
De novo mutations in HCN1 cause early infantile epileptic encephalopathy
Hyperpolarization-activated, cyclic nucleotide–gated (HCN) channels contribute to cationic I
h current in neurons and regulate the excitability of neuronal networks. Studies in rat models …
h current in neurons and regulate the excitability of neuronal networks. Studies in rat models …
Cardiac and neuronal HCN channelopathies
I Rivolta, A Binda, A Masi, JC DiFrancesco - Pflügers Archiv-European …, 2020 - Springer
Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are expressed as four
different isoforms (HCN1-4) in the heart and in the central and peripheral nervous systems …
different isoforms (HCN1-4) in the heart and in the central and peripheral nervous systems …
HCN channelopathy in external globus pallidus neurons in models of Parkinson's disease
CS Chan, KE Glajch, TS Gertler, JN Guzman… - Nature …, 2011 - nature.com
Parkinson's disease is a common neurodegenerative disorder characterized by a profound
motor disability that is traceable to the emergence of synchronous, rhythmic spiking in …
motor disability that is traceable to the emergence of synchronous, rhythmic spiking in …
Dysfunctional HCN ion channels in neurological diseases
JC DiFrancesco, D DiFrancesco - Frontiers in cellular neuroscience, 2015 - frontiersin.org
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are expressed as four
different isoforms (HCN1-4) in the heart and in the central and peripheral nervous systems …
different isoforms (HCN1-4) in the heart and in the central and peripheral nervous systems …
Modelling epilepsy in the mouse: challenges and solutions
GF Marshall, A Gonzalez-Sulser… - Disease models & …, 2021 - journals.biologists.com
In most mouse models of disease, the outward manifestation of a disorder can be measured
easily, can be assessed with a trivial test such as hind limb clasping, or can even be …
easily, can be assessed with a trivial test such as hind limb clasping, or can even be …
Alternatively spliced isoforms of TRIP8b differentially control h channel trafficking and function
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels (h channels) are the
molecular basis for the current, I h, which contributes crucially to intrinsic neuronal …
molecular basis for the current, I h, which contributes crucially to intrinsic neuronal …
Deletion of the hyperpolarization-activated cyclic nucleotide-gated channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes …
Output properties of neurons are greatly shaped by voltage-gated ion channels, whose
biophysical properties and localization within axodendritic compartments serve to …
biophysical properties and localization within axodendritic compartments serve to …