Cognitive mechanisms of treatment in depression
Cognitive abnormalities are a core feature of depression, and biases toward negatively
toned emotional information are common, but are they a cause or a consequence of …
toned emotional information are common, but are they a cause or a consequence of …
Personalized medicine for depression: can we match patients with treatments?
Objective: Response to specific depression treatments varies widely among individuals.
Understanding and predicting that variation could have great benefits for people living with …
Understanding and predicting that variation could have great benefits for people living with …
[HTML][HTML] A mega-analysis of genome-wide association studies for major depressive disorder
Major Depressive Disorder Working Group of … - Molecular …, 2013 - ncbi.nlm.nih.gov
Prior genome-wide association studies (GWAS) of major depressive disorder (MDD) have
met with limited success. We sought to increase statistical power to detect disease loci by …
met with limited success. We sought to increase statistical power to detect disease loci by …
The Personalized Advantage Index: translating research on prediction into individualized treatment recommendations. A demonstration
Background Advances in personalized medicine require the identification of variables that
predict differential response to treatments as well as the development and refinement of …
predict differential response to treatments as well as the development and refinement of …
Toward a neuroimaging treatment selection biomarker for major depressive disorder
CL McGrath, ME Kelley, PE Holtzheimer… - JAMA …, 2013 - jamanetwork.com
Importance Currently, fewer than 40% of patients treated for major depressive disorder
achieve remission with initial treatment. Identification of a biological marker that might …
achieve remission with initial treatment. Identification of a biological marker that might …
[HTML][HTML] Genome-wide association for major depression through age at onset stratification: major depressive disorder working group of the psychiatric genomics …
Background Major depressive disorder (MDD) is a disabling mood disorder, and despite a
known heritable component, a large meta-analysis of genome-wide association studies …
known heritable component, a large meta-analysis of genome-wide association studies …
Personalized medicine in psychiatry: problems and promises
U Ozomaro, C Wahlestedt, CB Nemeroff - BMC medicine, 2013 - Springer
The central theme of personalized medicine is the premise that an individual's unique
physiologic characteristics play a significant role in both disease vulnerability and in …
physiologic characteristics play a significant role in both disease vulnerability and in …
Peripheral biomarkers of major depression and antidepressant treatment response: current knowledge and future outlooks
Background In recent years, we have accomplished a deeper understanding about the
pathophysiology of major depressive disorder (MDD). Nevertheless, this improved …
pathophysiology of major depressive disorder (MDD). Nevertheless, this improved …
Genome-wide pharmacogenetics of antidepressant response in the GENDEP project
Objective The purpose of this study was to identify genetic variants underlying the
considerable individual differences in response to antidepressant treatment. The authors …
considerable individual differences in response to antidepressant treatment. The authors …
Predicting treatment response in social anxiety disorder from functional magnetic resonance imaging
O Doehrmann, SS Ghosh, FE Polli… - JAMA …, 2013 - jamanetwork.com
Context Current behavioral measures poorly predict treatment outcome in social anxiety
disorder (SAD). To our knowledge, this is the first study to examine neuroimaging-based …
disorder (SAD). To our knowledge, this is the first study to examine neuroimaging-based …