A molecular motor is made of either a single macromolecule or a macromolecular complex.
Just like their macroscopic counterparts, molecular motors “transduce” input energy into …

Mitosis is the process by which eukaryotic cells organize and segregate their chromosomes
in preparation for cell division. It is accomplished by a cellular machine composed largely of …

The essential functions required for mitotic spindle assembly and chromosome biorientation
and segregation are not fully understood, despite extensive study. To illuminate the …

Kinetochores bound to kinetochore microtubules (kMTs) exhibit directional instability in
mammalian and other mitotic vertebrate cells, oscillating between poleward (P) and away …

To achieve chromosome segregation during mitosis, sister chromatids must undergo a
dramatic change in their behavior to switch from balanced oscillations at the metaphase …

For over 70 years, chromosomes have been known to oscillate back-and-forth on the
metaphase plate. These movements are directed by kinetochores, the microtubule …

Duplicated mitotic chromosomes aligned at the metaphase plate maintain dynamic
attachments to spindle microtubules via their kinetochores, and multiple motor and nonmotor …

ABSTRACT A universal feature of mitosis is that all chromosomes become aligned at the
spindle equator–the halfway point between the two spindle poles–prior to anaphase onset …

Mitosis is the process by which the genome is segregated to form two identical daughter
cells during cell division. The process of cell division is essential to the maintenance of every …

Kinetochores are multi-protein complexes that mediate the physical coupling of sister
chromatids to spindle microtubule bundles (called kinetochore (K)-fibres) from respective …