[HTML][HTML] miRNAs as biomarkers in disease: latest findings regarding their role in diagnosis and prognosis

CE Condrat, DC Thompson, MG Barbu, OL Bugnar… - Cells, 2020 - mdpi.com
MicroRNAs (miRNAs) represent a class of small, non-coding RNAs with the main roles of
regulating mRNA through its degradation and adjusting protein levels. In recent years …

[HTML][HTML] MicroRNAs in stress signaling and human disease

JT Mendell, EN Olson - Cell, 2012 - cell.com
Disease is often the result of an aberrant or inadequate response to physiologic and
pathophysiologic stress. Studies over the last 10 years have uncovered a recurring …

MicroRNAs in body fluids—the mix of hormones and biomarkers

MA Cortez, C Bueso-Ramos, J Ferdin… - Nature reviews Clinical …, 2011 - nature.com
Since the discovery of microRNAs (miRNAs), the study of these small noncoding RNAs has
steadily increased and more than 10,000 papers have already been published. The great …

MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy

AL Kasinski, FJ Slack - Nature Reviews Cancer, 2011 - nature.com
In normal cells multiple microRNAs (miRNAs) converge to maintain a proper balance of
various processes, including proliferation, differentiation and cell death. miRNA …

Genetic variation in microRNA networks: the implications for cancer research

BM Ryan, AI Robles, CC Harris - Nature reviews cancer, 2010 - nature.com
Many studies have highlighted the role that microRNAs have in physiological processes and
how their deregulation can lead to cancer. More recently, it has been proposed that the …

[HTML][HTML] Regulatory mechanisms of epigenetic miRNA relationships in human cancer and potential as therapeutic targets

KMT Arif, EK Elliott, LM Haupt, LR Griffiths - Cancers, 2020 - mdpi.com
Simple Summary By the virtue of targeting multiple genes, a microRNA (miRNA) can infer
variable consequences on tumorigenesis by appearing as both a tumour suppressor and …

MicroRNAs and epigenetics

F Sato, S Tsuchiya, SJ Meltzer, K Shimizu - The FEBS journal, 2011 - Wiley Online Library
MicroRNAs (miRNAs) comprise species of short noncoding RNA that regulate gene
expression post‐transcriptionally. Recent studies have demonstrated that epigenetic …

MicroRNA sequence and expression analysis in breast tumors by deep sequencing

TA Farazi, HM Horlings, JJ Ten Hoeve, A Mihailovic… - Cancer research, 2011 - AACR
MicroRNAs (miRNA) regulate many genes critical for tumorigenesis. We profiled miRNAs
from 11 normal breast tissues, 17 noninvasive, 151 invasive breast carcinomas, and 6 cell …

miRNA dysregulation in breast cancer

L Mulrane, SF McGee, WM Gallagher, DP O'Connor - Cancer research, 2013 - AACR
Abstract miRNAs have emerged, in the last decade, as key players in the carcinogenic
process, with many candidates identified as playing important roles in many aspects of …

[HTML][HTML] MicroRNAs involved in carcinogenesis, prognosis, therapeutic resistance, and applications in human triple-negative breast cancer

L Ding, H Gu, X Xiong, H Ao, J Cao, W Lin, M Yu, J Lin… - Cells, 2019 - mdpi.com
Triple-negative breast cancer (TNBC) is the most aggressive, prevalent, and distinct subtype
of breast cancer characterized by high recurrence rates and poor clinical prognosis, devoid …