Objectives Methotrexate (MTX) is a commonly used anti-cancer drug. However, its usage
could lead to various biochemical dysregulations culminating in organ toxicity. Globally …

Objective: Methotrexate (MTX) is a frontline antimetabolite anticancer drug which is used in
different cancer treatments but its nephrotoxicity is a notable drawback that limits its clinical …

Cyclophosphamide (CP) is a cytotoxic, cell cycle, non-specific, and antiproliferative drug.
This study aimed to address the toxic effects of CP on male fertility and the possible …

Edaravone (ED) is a neuroprotective drug with beneficial effects against several disorders
due to its prominent antioxidant activity. However, its effect against methotrexate (MTX) …

Oxidative stress occurs when there is an imbalance between the production of reactive
oxygen species (ROS) and the body's antioxidant defenses. It poses a significant threat to …

Testicular damage is considered a severe complication of cadmium (Cd) exposure which is
associated with tissue oxidative stress damage, inflammation, and apoptosis. The present …

Methotrexate (MTX) is commonly used as a therapeutic agent in the treatment of
malignancies and autoimmune disorders. Risk of subsequent infertility following MTX …

Cardiac toxicity is a public health issue that can be caused by both environmental and
occupational exposures. The current study aimed to investigate the effectiveness of …

Methotrexate (MTX) is a chemotherapeutic agent widely used to treat a variety of tumors.
Nonetheless, MTX‐induced hippocampal neurotoxicity is a well‐defined dose‐limiting …

Cisplatin (CDDP) is an effective chemotherapeutic drug that has been used successfully in
treating various tumors. Although its higher antineoplastic agent activity, CDDP exhibited …