The emergence of modern photocatalysis, characterized by mildness and selectivity, has
significantly spurred innovative late-stage C–H functionalization approaches that make use …

Redox processes are at the heart of synthetic methods that rely on either electrochemistry or
photoredox catalysis, but how do electrochemistry and photoredox catalysis compare? Both …

C–H functionalization reactions are playing an increasing role in the preparation and
modification of complex organic molecules, including pharmaceuticals, agrochemicals and …

This Perspective surveys the progress and current limitations of nucleophilic fluorination
methodologies. Despite the long and rich history of C (sp3)–F bond construction in chemical …

Radical reactivity is a powerful tool for molecular construction that often provides bond-
forming strategies and retrosynthetic disconnections complementary to those available …

Copper-catalyzed radical-relay reactions provide a versatile strategy for selective C–H
functionalization; however, reactions with peroxide-based oxidants often require excess C …

C (sp3) radicals (R˙) are of broad research interest and synthetic utility. This review collects
some of the most recent advancements in photocatalytic R˙ generation and highlights …

A visible-light photoredox-catalyzed method is reported that enables the coupling between
benzylic C–H substrates and N–H azoles. Classically, medicinally relevant N-benzyl azoles …

Functionalization of the benzylic C (sp 3)–H bond has become a compelling and robust tool
to speed up pre-clinical research for" lead discovery." Besides bring frequently utilizated to …

Stable isotopes such as 2H, 13C, and 15N have important applications in chemistry and
drug discovery. Late-stage incorporation of uncommon isotopes via isotopic exchange …