Tumor metastasis: Mechanistic insights and therapeutic interventions

M Liu, J Yang, B Xu, X Zhang - MedComm, 2021 - Wiley Online Library
Cancer metastasis is responsible for the vast majority of cancer‐related deaths worldwide. In
contrast to numerous discoveries that reveal the detailed mechanisms leading to the …

[HTML][HTML] The emerging role of non-coding RNAs in the regulation of PI3K/AKT pathway in the carcinogenesis process

S Ghafouri-Fard, A Abak, FT Anamag, H Shoorei… - Biomedicine & …, 2021 - Elsevier
Abstract The PI3K/AKT pathway is an intracellular signaling pathway with an indispensable
impact on cell cycle control. This pathway is functionally related with cell proliferation, cell …

lncRNA ITGB8-AS1 functions as a ceRNA to promote colorectal cancer growth and migration through integrin-mediated focal adhesion signaling

X Lin, S Zhuang, X Chen, J Du, L Zhong, J Ding… - Molecular Therapy, 2022 - cell.com
Long non-coding RNAs (lncRNAs) play critical roles in tumorigenesis and progression of
colorectal cancer (CRC). However, functions of most lncRNAs in CRC and their molecular …

DANCR promotes metastasis and proliferation in bladder cancer cells by enhancing IL-11-STAT3 signaling and CCND1 expression

Z Chen, X Chen, R Xie, M Huang, W Dong, J Han… - Molecular Therapy, 2019 - cell.com
The prognosis for patients with bladder cancer (BCa) with lymph node (LN) metastasis is
poor, and it is not improved by current treatments. Long noncoding RNAs (lncRNAs) are …

Novel function of lncRNA ADAMTS9-AS2 in promoting temozolomide resistance in glioblastoma via upregulating the FUS/MDM2 ubiquitination axis

Y Yan, Z Xu, X Chen, X Wang, S Zeng… - Frontiers in Cell and …, 2019 - frontiersin.org
Background LncRNAs have been shown to play essential roles in cancer therapeutic
response. However, the detailed mechanism of lncRNAs in temozolomide (TMZ) resistance …

Targeting long non-coding RNA to therapeutically regulate gene expression in cancer

D Fu, Y Shi, JB Liu, TM Wu, CY Jia, HQ Yang… - … Therapy-Nucleic Acids, 2020 - cell.com
Long-chain non-coding RNAs (lncRNAs) are RNA molecules with a length greater than 200
nt and no function of encoding proteins. lncRNAs play a precise regulatory function at …

Regulation and functions of α6-integrin (CD49f) in Cancer biology

R Khademi, H Malekzadeh, S Bahrami, N Saki… - Cancers, 2023 - mdpi.com
Simple Summary Integrins play key roles in mediating cell adhesion and delivering chemical
and mechanical signals to the interior of the cell. Consequently, they actively control cellular …

The current landscape of the antimicrobial peptide melittin and its therapeutic potential

HQ Zhang, C Sun, N Xu, W Liu - Frontiers in Immunology, 2024 - frontiersin.org
Melittin, a main component of bee venom, is a cationic amphiphilic peptide with a linear α-
helix structure. It has been reported that melittin can exert pharmacological effects, such as …

[HTML][HTML] The role of lncRNAs and exosomal lncRNAs in cancer metastasis

Y Zhang, L Zhao, Y Bi, J Zhao, C Gao, X Si… - Biomedicine & …, 2023 - Elsevier
Tumor metastasis is the main reason for cancer-related death, but there is still a lack of
effective therapeutic to inhibit tumor metastasis. Therefore, the discovery and study of new …

Exosome‐derived long non‐coding RNA ADAMTS9‐AS2 suppresses progression of oral submucous fibrosis via AKT signalling pathway

S Zhou, Y Zhu, Z Li, Y Zhu, Z He… - Journal of Cellular and …, 2021 - Wiley Online Library
Oral submucosal fibrosis (OSF) is one of the pre‐cancerous lesions of oral squamous cell
carcinoma (OSCC). Its malignant rate is increasing, but the mechanism of malignancy is not …