Endocannabinoid modulation of dopamine neurotransmission
Dopamine (DA) is a major catecholamine neurotransmitter in the mammalian brain that
controls neural circuits involved in the cognitive, emotional, and motor aspects of goal …
controls neural circuits involved in the cognitive, emotional, and motor aspects of goal …
Dopamine's effects on corticostriatal synapses during reward-based behaviors
NS Bamford, RM Wightman, D Sulzer - Neuron, 2018 - cell.com
Many learned responses depend on the coordinated activation and inhibition of synaptic
pathways in the striatum. Local dopamine neurotransmission acts in concert with a variety of …
pathways in the striatum. Local dopamine neurotransmission acts in concert with a variety of …
VTA dopamine neuron activity encodes social interaction and promotes reinforcement learning through social prediction error
C Solié, B Girard, B Righetti, M Tapparel… - Nature …, 2022 - nature.com
Social interactions are motivated behaviors that, in many species, facilitate learning.
However, how the brain encodes the reinforcing properties of social interactions remains …
However, how the brain encodes the reinforcing properties of social interactions remains …
Dopamine deficiency reduces striatal cholinergic interneuron function in models of Parkinson's disease
Motor and cognitive functions depend on the coordinated interactions between dopamine
(DA) and acetylcholine (ACh) at striatal synapses. Increased ACh availability was assumed …
(DA) and acetylcholine (ACh) at striatal synapses. Increased ACh availability was assumed …
Alterations in the intrinsic properties of striatal cholinergic interneurons after dopamine lesion and chronic L-DOPA
Changes in striatal cholinergic interneuron (ChI) activity are thought to contribute to
Parkinson's disease pathophysiology and dyskinesia from chronic L-3, 4 …
Parkinson's disease pathophysiology and dyskinesia from chronic L-3, 4 …
μ-Opioid receptors on distinct neuronal populations mediate different aspects of opioid reward-related behaviors
AL Severino, N Mittal, JK Hakimian, N Velarde… - eneuro, 2020 - eneuro.org
Abstract μ-Opioid receptors (MORs) are densely expressed in different brain regions known
to mediate reward. One such region is the striatum where MORs are densely expressed, yet …
to mediate reward. One such region is the striatum where MORs are densely expressed, yet …
Dietary supplementation with omega-3 polyunsaturated fatty acids reduces opioid-seeking behaviors and alters the gut microbiome
JK Hakimian, TS Dong, JA Barahona, V Lagishetty… - Nutrients, 2019 - mdpi.com
Opioids are highly addictive substances with a relapse rate of over 90%. While preclinical
models of chronic opioid exposure exist for studying opioid dependence, none recapitulate …
models of chronic opioid exposure exist for studying opioid dependence, none recapitulate …
The abnormal firing of Purkinje cells in the knockin mouse model of DYT1 dystonia
DYT1 dystonia is an inherited movement disorder caused by a heterozygous trinucleotide
(GAG) deletion in DYT1/TOR1A, coding for torsinA. Growing evidence suggests that the …
(GAG) deletion in DYT1/TOR1A, coding for torsinA. Growing evidence suggests that the …
Complex control of striatal neurotransmission by nicotinic acetylcholine receptors via excitatory inputs onto medium spiny neurons
The prevalence of nicotine dependence is higher than that for any other substance abuse
disorder; still, the underlying mechanisms are not fully established. To this end, we studied …
disorder; still, the underlying mechanisms are not fully established. To this end, we studied …
Top-down circuitry from the anterior insular cortex to VTA dopamine neurons modulates reward-related memory
The insular cortex (IC) has been linked to the processing of interoceptive and exteroceptive
signals associated with addictive behavior. However, whether the IC modulates the …
signals associated with addictive behavior. However, whether the IC modulates the …