Intravenous β‐lactam antibiotics remain a cornerstone in the management of bacterial
infections due to their broad spectrum of activity and excellent tolerability. β‐lactams are well …

These good practice recommendations for outpatient parenteral antimicrobial therapy
(OPAT) are an update to a previous consensus statement on OPAT in the UK published in …

INTRODUCTION: Seizure liability is an adverse property of new candidate drugs typically
detected only in later stage pre-clinical safety studies. Consequently, pharmaceutical …

Objectives Thermal stability is a key property in determining the suitability of an antibiotic
agent for local application in the treatment of orthopaedic infections. Despite the fact that …

Killing of bacteria by β-lactam antibiotics is maximal at around four times the minimum
inhibitory concentration in vitro. To ensure an optimal effect when treating severe infections …

Laboratory assays such as MIC tests assume that antibiotic molecules are stable in the
chosen growth medium—but rapid degradation has been observed for antibiotics including …

Over several decades, the economic situation and consideration of patient quality of life
have been responsible for increased outpatient treatment. It is in this context that outpatient …

The emergence of bacterial resistance and the lack of new antibiotics in the pipeline
represent a public health priority. Maximizing the quality of antibiotic prescriptions is …

The modern chemotherapy era started with Fleming's discovery of benzylpenicillin. He
demonstrated that benzylpenicillin did not kill Mycobacterium tuberculosis. In this study, we …

The alarming global rise of antimicrobial resistance combined with the lack of new
antimicrobial agents has led to a renewed interest in optimization of our current antibiotics …