Understanding microRNA-mediated gene regulatory networks through mathematical modelling
The discovery of microRNAs (miRNAs) has added a new player to the regulation of gene
expression. With the increasing number of molecular species involved in gene regulatory …
expression. With the increasing number of molecular species involved in gene regulatory …
Novel extended mixed controller design for bifurcation control of fractional‐order Myc/E2F/miR‐17‐92 network model concerning delay
P Li, X Peng, C Xu, L Han, S Shi - Mathematical Methods in the …, 2023 - Wiley Online Library
MiR‐17‐92 has a vital effect on the adjustment of the Myc/E2F protein in chemistry. In this
work, we propose a novel fractional‐order delayed Myc/E2F/miR‐17‐92 network model that …
work, we propose a novel fractional‐order delayed Myc/E2F/miR‐17‐92 network model that …
[HTML][HTML] MicroRNAs and ovarian function
J Baley, J Li - Journal of ovarian research, 2012 - Springer
MicroRNAs (miRNAs) are a class of small non-coding RNAs which function in gene
regulation with an important role in cell proliferation, maturation, and activity. The regulatory …
regulation with an important role in cell proliferation, maturation, and activity. The regulatory …
[PDF][PDF] A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells
Summary microRNAs regulate developmental cell-fate decisions, tissue homeostasis, and
oncogenesis in distinct ways relative to proteins. Here, we show that the tumor suppressor …
oncogenesis in distinct ways relative to proteins. Here, we show that the tumor suppressor …
Micro-RNA378 (miR-378) regulates ovarian estradiol production by targeting aromatase
Estradiol is a steroid hormone that not only plays an important role in ovarian follicular
development but also is associated with many reproductive disorders. Owing to the …
development but also is associated with many reproductive disorders. Owing to the …
microRNA-9 regulates axon extension and branching by targeting Map1b in mouse cortical neurons
The capacity of neurons to develop a long axon and multiple dendrites defines neuron
connectivity in the CNS. The highly conserved microRNA-9 (miR-9) is expressed in both …
connectivity in the CNS. The highly conserved microRNA-9 (miR-9) is expressed in both …
[PDF][PDF] MicroRNA-9 modulates Hes1 ultradian oscillations by forming a double-negative feedback loop
B Bonev, P Stanley, N Papalopulu - Cell reports, 2012 - cell.com
Short-period (ultradian) oscillations of Hes1, a Notch signaling effector, are essential for
maintaining neural progenitors in a proliferative state, while constitutive downregulation of …
maintaining neural progenitors in a proliferative state, while constitutive downregulation of …
[PDF][PDF] MicroRNA-9 reveals regional diversity of neural progenitors along the anterior-posterior axis
Neural progenitors self-renew and generate neurons throughout the central nervous system.
Here, we uncover an unexpected regional specificity in the properties of neural progenitor …
Here, we uncover an unexpected regional specificity in the properties of neural progenitor …
[HTML][HTML] miR-21 promotes human nucleus pulposus cell proliferation through PTEN/AKT signaling
H Liu, X Huang, X Liu, S Xiao, Y Zhang… - International journal of …, 2014 - mdpi.com
The precise role of nucleus pulposus cell proliferation in the pathogenesis of intervertebral
disc degeneration remains to be elucidated. Recent findings have revealed that microRNAs …
disc degeneration remains to be elucidated. Recent findings have revealed that microRNAs …
Mitochondria: one of the destinations of miRNAs
The cellular processes are controlled by a narrow range of mRNA and proteins levels,
where small RNAs (sRNAs) known as miRNAs play a critical role. The spatial and temporal …
where small RNAs (sRNAs) known as miRNAs play a critical role. The spatial and temporal …