Structural mechanisms of autoinhibition and substrate recognition by the ubiquitin ligase HACE1
J Düring, M Wolter, JJ Toplak, C Torres… - Nature Structural & …, 2024 - nature.com
Ubiquitin ligases (E3s) are pivotal specificity determinants in the ubiquitin system by
selecting substrates and decorating them with distinct ubiquitin signals. However, structure …
selecting substrates and decorating them with distinct ubiquitin signals. However, structure …
Rac1 promotes kidney collecting duct repair by mechanically coupling cell morphology to mitotic entry
F Bock, X Dong, S Li, OM Viquez, E Sha… - Science …, 2024 - science.org
Prolonged obstruction of the ureter, which leads to injury of the kidney collecting ducts,
results in permanent structural damage, while early reversal allows for repair. Cell structure …
results in permanent structural damage, while early reversal allows for repair. Cell structure …
Determining the ubiquitylation mechanism of UBR5
LA Hehl - 2024 - mediatum.ub.tum.de
HECT E3 ligases play a crucial role in regulating cellular processes through linkage-specific
ubiquitin chain formation. Malfunctions contribute to various diseases, yet the structural …
ubiquitin chain formation. Malfunctions contribute to various diseases, yet the structural …