Parkinson's disease (PD) is a slow insidious neurological disorder characterized by a loss of
dopaminergic neurons in the midbrain. Although several recent preclinical advances have …

The basal ganglia (BG) are a collection of interconnected subcortical nuclei that participate
in a great variety of functions, ranging from motor programming and execution to procedural …

Parkinson's disease (PD) is histologically characterized by the accumulation of α-synuclein
particles, known as Lewy bodies. The second most common neurodegenerative disorder …

With the increase of life expectancy, neurodegenerative disorders are becoming not only a
health but also a social burden worldwide. However, due to the multitude of …

The focus of this literature review is on the three interacting brain areas that participate in
decision‐making: basal ganglia, ventral motor thalamic nuclei, and medial prefrontal cortex …

As the main input nucleus of the basal ganglion, the striatum executes different functions,
including motivation, reward and attention. The functions of the striatum highly rely on its …

The current treatment of Parkinson's disease with dopamine-centric approaches such as L-
DOPA and dopamine agonists, although very successful, is in need of alternative treatment …

The basal ganglia (BG) control action selection, motor programs, habits, and goal-directed
learning. The striatum, the principal input structure of BG, is predominantly composed of …

Impairments of synaptic plasticity are a hallmark of several neurological disorders, including
Parkinson9s disease (PD) which results from the progressive loss of dopaminergic neurons …

Dopamine (DA) depletion modifies the firing pattern of neurons in the substantia nigra pars
reticulata (SNr), shifting their mostly tonic firing toward irregularity and bursting, traits of …