Regulating the 20S proteasome ubiquitin-independent degradation pathway
G Ben-Nissan, M Sharon - Biomolecules, 2014 - mdpi.com
For many years, the ubiquitin-26S proteasome degradation pathway was considered the
primary route for proteasomal degradation. However, it is now becoming clear that proteins …
primary route for proteasomal degradation. However, it is now becoming clear that proteins …
[HTML][HTML] The MDM2-p53 pathway revisited
The p53 tumor suppressor is a key transcription factor regulating cellular pathways such as
DNA repair, cell cycle, apoptosis, angiogenesis, and senescence. It acts as an important …
DNA repair, cell cycle, apoptosis, angiogenesis, and senescence. It acts as an important …
A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance
D Chauhan, Z Tian, B Nicholson, KGS Kumar, B Zhou… - Cancer cell, 2012 - cell.com
Bortezomib therapy has proven successful for the treatment of relapsed/refractory, relapsed,
and newly diagnosed multiple myeloma (MM); however, dose-limiting toxicities and the …
and newly diagnosed multiple myeloma (MM); however, dose-limiting toxicities and the …
Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets
L Bedford, J Lowe, LR Dick, RJ Mayer… - Nature reviews Drug …, 2011 - nature.com
The ubiquitin–proteasome system (UPS) and ubiquitin-like protein (UBL) conjugation
pathways are integral to cellular protein homeostasis. The growing recognition of the …
pathways are integral to cellular protein homeostasis. The growing recognition of the …
Nucleolar stress with and without p53
A veritable explosion of primary research papers within the past 10 years focuses on
nucleolar and ribosomal stress, and for good reason: with ribosome biosynthesis …
nucleolar and ribosomal stress, and for good reason: with ribosome biosynthesis …
Multiple roles of the cell cycle inhibitor p21CDKN1A in the DNA damage response
Among cell cycle regulatory proteins that are activated following DNA damage, the cyclin-
dependent kinase inhibitor p21CDKN1A plays essential roles in the DNA damage response …
dependent kinase inhibitor p21CDKN1A plays essential roles in the DNA damage response …
Examination of the expanding pathways for the regulation of p21 expression and activity
p21Waf1/Cip1/Sdi1 was originally identified as an inhibitor of cyclin-dependent kinases, a
mediator of p53 in growth suppression and a marker of cellular senescence. p21 is required …
mediator of p53 in growth suppression and a marker of cellular senescence. p21 is required …
Drug discovery in the ubiquitin–proteasome system
G Nalepa, M Rolfe, JW Harper - Nature reviews Drug discovery, 2006 - nature.com
Regulated protein turnover via the ubiquitin–proteasome system (UPS) underlies a wide
variety of signalling pathways, from cell-cycle control and transcription to development …
variety of signalling pathways, from cell-cycle control and transcription to development …
MDM2 inhibitors for cancer therapy
LT Vassilev - Trends in molecular medicine, 2007 - cell.com
The tumor suppressor p53 is a powerful antitumoral molecule frequently inactivated by
mutations or deletions in cancer. However, half of all human tumors express wild-type p53 …
mutations or deletions in cancer. However, half of all human tumors express wild-type p53 …
Structural disorder throws new light on moonlighting
A basic mechanism by which individual proteins can increase network complexity is
moonlighting, whereby a given protein fulfils more than one function. Traditionally, this …
moonlighting, whereby a given protein fulfils more than one function. Traditionally, this …